Hongling Yang1, Wen Tang, Chunyan Zhu, Caijiao Guo. 1. Department of Clinical Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, 510623, China.
Abstract
OBJECTIVE: To assess the features of the platelets (PLTs) of hypertensive disorders of pregnancy (HDP) and to determine whether they have a predictive value for the disorders during the preclinical stage. METHODS: This study included 461 HDPs and 827 normal pregnancies. Platelet counts were compared between the two groups by an independent samples t test; a Fisher's linear discriminant analysis and receiver operator characteristic curve were performed to analyze the diagnostic effects of the variables in developing HDP. RESULTS: Women with HDP had significantly higher PLT before the second trimester. When exceeding the cut-off, it had a specificity (SPE) of 81.67% (95% CI: 81.63%-81.72%) for predicting a HDP. The discriminant function had a sensitivity of 69.1 (95% CI: 69.04-69.16), a SPE of 73.60% (95% CI: 73.569-73.64), a positive prediction value of 61.32% (95% CI: 61.25-61.39), a negative prediction value of 79.93% (95% CI: 79.88-79.98), and 71.50% of gravidas were correctly classified. CONCLUSION: These results show that HDP is associated with increased systemic inflammation as depicted by the PLT and white blood cells in gravidas. The discriminant function of blood cells in a mathematical model may be helpful for predicting a HDP in presymptomatic patients, however, which is not sufficiently to use in clinical practice; a prospective study about the predicting is still needed.
OBJECTIVE: To assess the features of the platelets (PLTs) of hypertensive disorders of pregnancy (HDP) and to determine whether they have a predictive value for the disorders during the preclinical stage. METHODS: This study included 461 HDPs and 827 normal pregnancies. Platelet counts were compared between the two groups by an independent samples t test; a Fisher's linear discriminant analysis and receiver operator characteristic curve were performed to analyze the diagnostic effects of the variables in developing HDP. RESULTS:Women with HDP had significantly higher PLT before the second trimester. When exceeding the cut-off, it had a specificity (SPE) of 81.67% (95% CI: 81.63%-81.72%) for predicting a HDP. The discriminant function had a sensitivity of 69.1 (95% CI: 69.04-69.16), a SPE of 73.60% (95% CI: 73.569-73.64), a positive prediction value of 61.32% (95% CI: 61.25-61.39), a negative prediction value of 79.93% (95% CI: 79.88-79.98), and 71.50% of gravidas were correctly classified. CONCLUSION: These results show that HDP is associated with increased systemic inflammation as depicted by the PLT and white blood cells in gravidas. The discriminant function of blood cells in a mathematical model may be helpful for predicting a HDP in presymptomatic patients, however, which is not sufficiently to use in clinical practice; a prospective study about the predicting is still needed.