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Literature DB >> 21402355

Essential ingredients for HIV-1 budding.

Winfried Weissenhorn¹, Heinrich Göttlinger².

Abstract

HIV-1 engages the cellular ESCRT-III/VPS4 membrane scission machinery for its escape from host cells. Three papers now begin to demystify its mode of action by showing that HIV-1 requires only the transient recruitment of a surprisingly small subset of ESCRT-III components, whose membrane abscission function depends on VPS4 activity.

Entities: Gene Species

Year: 2011 PMID： 21402355 DOI： 10.1016/j.chom.2011.03.005

Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023

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Cited

9 in total

1. The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.

Authors: Paola Sette; Ruiling Mu; Vincent Dussupt; Jiansheng Jiang; Greg Snyder; Patrick Smith; Tsan Sam Xiao; Fadila Bouamr
Journal: Structure Date: 2011-09-01 Impact factor: 5.006

2. ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.

Authors: Ziying Han; Jonathan J Madara; Yuliang Liu; Wenbo Liu; Gordon Ruthel; Bruce D Freedman; Ronald N Harty
Journal: J Infect Dis Date: 2015-03-18 Impact factor: 5.226

3. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

Authors: Monica Agromayor; Nicolas Soler; Anna Caballe; Tonya Kueck; Stefan M Freund; Mark D Allen; Mark Bycroft; Olga Perisic; Yu Ye; Bethan McDonald; Hartmut Scheel; Kay Hofmann; Stuart J D Neil; Juan Martin-Serrano; Roger L Williams
Journal: Structure Date: 2012-03-07 Impact factor: 5.006

Essential ingredients for HIV-1 budding.

1. The Phe105 loop of Alix Bro1 domain plays a key role in HIV-1 release.

2. ALIX Rescues Budding of a Double PTAP/PPEY L-Domain Deletion Mutant of Ebola VP40: A Role for ALIX in Ebola Virus Egress.

3. The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

4. Super-resolution imaging of ESCRT-proteins at HIV-1 assembly sites.

5. Abrogating ALIX Interactions Results in Stuttering of the ESCRT Machinery.

Review 6. Application of Advanced Light Microscopy to the Study of HIV and Its Interactions with the Host.

7. ESCRT-independent budding of HIV-1 gag virus-like particles from Saccharomyces cerevisiae spheroplasts.

8. Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding.

9. HIV-1 nucleocapsid and ESCRT-component Tsg101 interplay prevents HIV from turning into a DNA-containing virus.