Literature DB >> 21401508

The state of the art in anti-malarial drug discovery and development.

Jeremy N Burrows1, Kelly Chibale, Timothy N C Wells.   

Abstract

Malaria is one of the most prevalent and devastating infectious diseases of our time. Yet, unfortunately, apart from artemisinin combination therapies there are relatively few effective treatments for Plasmodium falciparum and only one treatment for the radical cure of Plasmodium vivax. Novel classes of antimalarial medicines are urgently needed given the long-term inevitability of resistance to current therapies and the need for drugs that are well tolerated by all. This review summarises the antimalarials developed and registered thus far, as well as describing some of the new small molecule therapy approaches being developed as a contribution towards the malaria eradication agenda.

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Year:  2011        PMID： 21401508     DOI： 10.2174/156802611795429194

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  46 in total

1.  Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.

Authors:  Rachel D Slack; Bryan T Mott; Lauren E Woodard; Abhai Tripathi; Abhai Triphati; David Sullivan; Elizabeth Nenortas; Sonya C T Girdwood; Theresa A Shapiro; Gary H Posner
Journal:  J Med Chem       Date:  2011-12-15       Impact factor: 7.446

2.  Re-engineering aryl methylcarbamates to confer high selectivity for inhibition of Anopheles gambiae versus human acetylcholinesterase.

Authors:  Joshua A Hartsel; Dawn M Wong; James M Mutunga; Ming Ma; Troy D Anderson; Ania Wysinski; Rafique Islam; Eric A Wong; Sally L Paulson; Jianyong Li; Polo C H Lam; Maxim M Totrov; Jeffrey R Bloomquist; Paul R Carlier
Journal:  Bioorg Med Chem Lett       Date:  2012-06-06       Impact factor: 2.823

3.  Artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression in a mouse model via enhancing autophagy.

Authors:  Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Journal:  Br J Pharmacol       Date:  2020-07-06       Impact factor: 8.739

Review 4.  Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.

Authors:  Robert L Summers; Megan N Nash; Rowena E Martin
Journal:  Cell Mol Life Sci       Date:  2012-06       Impact factor: 9.261

Review 5.  Global phenotypic screening for antimalarials.

Authors:  W Armand Guiguemde; Anang A Shelat; Jose F Garcia-Bustos; Thierry T Diagana; Francisco-Javier Gamo; R Kiplin Guy
Journal:  Chem Biol       Date:  2012-01-27

6.  Synthesis and antiplasmodial and antimycobacterial evaluation of new nitroimidazole and nitroimidazooxazine derivatives.

Authors:  Matshawandile Tukulula; Rajni-Kant Sharma; Maïa Meurillon; Aman Mahajan; Krupa Naran; Digby Warner; Jianxing Huang; Belew Mekonnen; Kelly Chibale
Journal:  ACS Med Chem Lett       Date:  2012-11-26       Impact factor: 4.345

7.  Evaluation of aminohydantoins as a novel class of antimalarial agents.

Authors:  Marvin J Meyers; Micky D Tortorella; Jing Xu; Limei Qin; Zhengxiang He; Xingfen Lang; Wentian Zeng; Wanwan Xu; Li Qin; Michael J Prinsen; Francis M Sverdrup; Christopher S Eickhoff; David W Griggs; Jonathan Oliva; Peter G Ruminski; E Jon Jacobsen; Mary A Campbell; David C Wood; Daniel E Goldberg; Xiaorong Liu; Yongzhi Lu; Xin Lu; Zhengchao Tu; Xiaoyun Lu; Ke Ding; Xiaoping Chen
Journal:  ACS Med Chem Lett       Date:  2013-12-06       Impact factor: 4.345

8.  Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target.

Authors:  Yongyuth Yuthavong; Bongkoch Tarnchompoo; Tirayut Vilaivan; Penchit Chitnumsub; Sumalee Kamchonwongpaisan; Susan A Charman; Danielle N McLennan; Karen L White; Livia Vivas; Emily Bongard; Chawanee Thongphanchang; Supannee Taweechai; Jarunee Vanichtanankul; Roonglawan Rattanajak; Uthai Arwon; Pascal Fantauzzi; Jirundon Yuvaniyama; William N Charman; David Matthews
Journal:  Proc Natl Acad Sci U S A       Date:  2012-10-03       Impact factor: 11.205

Review 9.  Malaria biology and disease pathogenesis: insights for new treatments.

Authors:  Louis H Miller; Hans C Ackerman; Xin-zhuan Su; Thomas E Wellems
Journal:  Nat Med       Date:  2013-02-06       Impact factor: 53.440

Review 10.  An evolutionary perspective on the kinome of malaria parasites.

Authors:  Eric Talevich; Andrew B Tobin; Natarajan Kannan; Christian Doerig
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2012-09-19       Impact factor: 6.237
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