Literature DB >> 21400750

[Triazavirin prophylactic efficacy against influenza virus A (H5N1)].

S Ia Loginova, S V Borisevich, V A Maksimov, V P Bondarev, S K Kotovskaia, V L Rusinov, V N Charushin, O N Chupakhin.   

Abstract

The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally infected with the influenza virus A/Chicken/Kurgan/Russia/02/05 vs. the reference drugs Tamiflu, Remantadin and Arbidol showed that in doses of 1 to 100 mg/kg it was efficient in the animal protection from death. The drug was also efficient in the urgent prophylaxis. Triazaverin effectively inhibited the influenza A virus multiplication in the lungs of the albino mice.

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Year:  2010        PMID: 21400750

Source DB:  PubMed          Journal:  Antibiot Khimioter        ISSN: 0235-2990


  1 in total

1.  Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties.

Authors:  Tatyana S Shestakova; Sergey L Deev; Igor А Khalymbadzha; Vladimir L Rusinov; Alexander S Paramonov; Alexander S Arseniev; Zakhar O Shenkarev; Valery N Charushin; Oleg N Chupakhin
Journal:  Chem Heterocycl Compd (N Y)       Date:  2021-05-12       Impact factor: 1.277

  1 in total

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