Literature DB >> 21400675

Genetic transformation of Borrelia burgdorferi.

Jenny A Hyde1, Eric H Weening, Jon T Skare.   

Abstract

The development of robust genetic tools to manipulate Borrelia burgdorferi, the etiologic agent of Lyme disease, now allows investigators to assess the role(s) of individual genes in the context of experimental Lyme borreliosis. This unit is devoted to the description of experimental approaches that are available for the molecular genetic analysis of B. burgdorferi with an emphasis on cultivation, electrotransformation, selection of desired mutants, and genetic complementation of acquired mutants. The intent is to provide a consensus protocol that encapsulates the methodologies currently employed by the B. burgdorferi research community and describe pertinent issues that must be accounted for when working with these pathogenic spirochetal bacteria.
© 2011 by John Wiley & Sons, Inc.

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Year:  2011        PMID： 21400675      PMCID： PMC3561735          DOI： 10.1002/9780471729259.mc12c04s20

Source DB:  PubMed          Journal:  Curr Protoc Microbiol


  56 in total

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Journal:  Nature       Date:  1997-12-11       Impact factor: 49.962

5.  Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes.

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Journal:  J Bacteriol       Date:  1997-01       Impact factor: 3.490

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Authors:  S W Barthold; D S Beck; G M Hansen; G A Terwilliger; K D Moody
Journal:  J Infect Dis       Date:  1990-07       Impact factor: 5.226

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Journal:  Lancet       Date:  1998-08-15       Impact factor: 79.321

8.  The urinary bladder, a consistent source of Borrelia burgdorferi in experimentally infected white-footed mice (Peromyscus leucopus).

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Journal:  J Clin Microbiol       Date:  1988-05       Impact factor: 5.948

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10.  Isolation and cultivation of Lyme disease spirochetes.

Authors:  A G Barbour
Journal:  Yale J Biol Med       Date:  1984 Jul-Aug
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  13 in total

1.  BB0744 Affects Tissue Tropism and Spatial Distribution of Borrelia burgdorferi.

Authors:  Beau Wager; Dana K Shaw; Ashley M Groshong; Jon S Blevins; Jon T Skare
Journal:  Infect Immun       Date:  2015-07-06       Impact factor: 3.441

2.  The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis.

Authors:  Hui Zhi; Eric H Weening; Elena Magda Barbu; Jenny A Hyde; Magnus Höök; Jon T Skare
Journal:  Mol Microbiol       Date:  2015-01-30       Impact factor: 3.501

3.  Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity.

Authors:  Jenny A Hyde; Eric H Weening; Mihee Chang; Jerome P Trzeciakowski; Magnus Höök; Jeffrey D Cirillo; Jon T Skare
Journal:  Mol Microbiol       Date:  2011-08-30       Impact factor: 3.501

4.  A selective antibiotic for Lyme disease.

Authors:  Nadja Leimer; Xiaoqian Wu; Yu Imai; Madeleine Morrissette; Norman Pitt; Quentin Favre-Godal; Akira Iinishi; Samta Jain; Mariaelena Caboni; Inga V Leus; Vincent Bonifay; Samantha Niles; Rachel Bargabos; Meghan Ghiglieri; Rachel Corsetti; Megan Krumpoch; Gabriel Fox; Sangkeun Son; Dorota Klepacki; Yury S Polikanov; Cecily A Freliech; Julie E McCarthy; Diane G Edmondson; Steven J Norris; Anthony D'Onofrio; Linden T Hu; Helen I Zgurskaya; Kim Lewis
Journal:  Cell       Date:  2021-10-06       Impact factor: 66.850

5.  pncA and bptA are not sufficient to complement Ixodes scapularis colonization and persistence by Borrelia burgdorferi in a linear plasmid lp25-deficient background.

Authors:  Robert D Gilmore; Kevin S Brandt; Jenny A Hyde
Journal:  Infect Immun       Date:  2014-09-22       Impact factor: 3.441

Review 6.  Genetic Manipulation of Borrelia.

Authors:  Patricia A Rosa; Mollie W Jewett
Journal:  Curr Issues Mol Biol       Date:  2020-12-10       Impact factor: 2.081

7.  Whole genome sequence of Treponema pallidum ssp. pallidum, strain Mexico A, suggests recombination between yaws and syphilis strains.

Authors:  Helena Pětrošová; Marie Zobaníková; Darina Čejková; Lenka Mikalová; Petra Pospíšilová; Michal Strouhal; Lei Chen; Xiang Qin; Donna M Muzny; George M Weinstock; David Šmajs
Journal:  PLoS Negl Trop Dis       Date:  2012-09-20

8.  Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family.

Authors:  Evelyn M Molloy; Sherwood R Casjens; Courtney L Cox; Tucker Maxson; Nicole A Ethridge; Gabriele Margos; Volker Fingerle; Douglas A Mitchell
Journal:  BMC Microbiol       Date:  2015-07-24       Impact factor: 3.605

9.  The Borrelia burgdorferi Adenylate Cyclase, CyaB, Is Important for Virulence Factor Production and Mammalian Infection.

Authors:  Vanessa M Ante; Lauren C Farris; Elizabeth P Saputra; Allie J Hall; Nathaniel S O'Bier; Adela S Oliva Chávez; Richard T Marconi; Meghan C Lybecker; Jenny A Hyde
Journal:  Front Microbiol       Date:  2021-05-25       Impact factor: 5.640

10.  In Vivo Imaging Demonstrates That Borrelia burgdorferi ospC Is Uniquely Expressed Temporally and Spatially throughout Experimental Infection.

Authors:  Jonathan T Skare; Dana K Shaw; Jerome P Trzeciakowski; Jenny A Hyde
Journal:  PLoS One       Date:  2016-09-09       Impact factor: 3.240
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