BACKGROUND: The purpose of this study was to compare 5-field and 7-field intensity-modulated radiation therapy (IMRT) techniques in terms of xerostomia and related quality of life in patients with nasopharyngeal cancer. METHODS: Eight and 23 patients were treated with 5-field (group I) and 7-field (group II) techniques, respectively. The xerostomia was evaluated using the Radiation Therapy Oncology Group (RTOG) scale, stimulated and unstimulated salivary flow (SSF/USF), and xerostomia-related questionnaires (XQs). The assessments were done before and at 3, 6, 12, 18, and 24 months after radiotherapy. RESULTS: The mean parotid dose was 45.7 Gy and 29.9 Gy and the ≥G3 toxicity at 24 months was 25% and 19% in group I and II, respectively. Sixty-three percent and 93% of patients recovered at least 25% of SSF pretherapy values. The XQ scores of both groups improved over time but more so in group II. CONCLUSION: The 7-field technique decreases the mean parotid dose, reducing xerostomia assessed by the RTOG/XQ score.
BACKGROUND: The purpose of this study was to compare 5-field and 7-field intensity-modulated radiation therapy (IMRT) techniques in terms of xerostomia and related quality of life in patients with nasopharyngeal cancer. METHODS: Eight and 23 patients were treated with 5-field (group I) and 7-field (group II) techniques, respectively. The xerostomia was evaluated using the Radiation Therapy Oncology Group (RTOG) scale, stimulated and unstimulated salivary flow (SSF/USF), and xerostomia-related questionnaires (XQs). The assessments were done before and at 3, 6, 12, 18, and 24 months after radiotherapy. RESULTS: The mean parotid dose was 45.7 Gy and 29.9 Gy and the ≥G3 toxicity at 24 months was 25% and 19% in group I and II, respectively. Sixty-three percent and 93% of patients recovered at least 25% of SSF pretherapy values. The XQ scores of both groups improved over time but more so in group II. CONCLUSION: The 7-field technique decreases the mean parotid dose, reducing xerostomia assessed by the RTOG/XQ score.
Authors: Margaret Patterson; Rowena Brain; Ronald Chin; David Veivers; Michael Back; Andrew Wignall; Thomas Eade Journal: Dysphagia Date: 2014-08-13 Impact factor: 3.438
Authors: Federica Pellegrino; Elena Groff; Luca Bastiani; Bruno Fattori; Guido Sotti Journal: Support Care Cancer Date: 2014-09-19 Impact factor: 3.603
Authors: T M Richards; T Hurley; L Grove; K J Harrington; G H Carpenter; G B Proctor; C M Nutting Journal: Oral Dis Date: 2017-06-05 Impact factor: 3.511
Authors: Alexandra E Quimby; Debora Hogan; Diana Khalil; Matthew Hearn; Colette Nault; Stephanie Johnson-Obaseki Journal: Int J Otolaryngol Date: 2020-08-06