| Literature DB >> 2140059 |
M D Mossalayi1, M Arock, J M Bertho, C Blanc, A H Dalloul, H Hofstetter, M Sarfati, G Delespesse, P Debré.
Abstract
Low affinity Fc epsilon receptors (Fc epsilon RII/CD23) or their soluble fragments have various biologic effects on B- and T-cell lineages. In this study, we have assessed the effect of recombinant soluble CD23 (rsCD23) on the proliferation of human bone marrow (BM)-derived myeloid precursors with or without recombinant interleukin-1 (rIL-1) addition. Non-adherent CD2- or CD34+ BM cell subsets were used as target cells. Our results show that rsCD23 in synergy with rIL-1 displays an interleukin-3-like activity as it promotes the proliferation of multipotential marrow precursors. This effect was abolished by anti-CD23 addition to these cultures, but was not affected by anti-IL-3 monoclonal antibody. Furthermore, sequential study indicates that rIL-1 induces bone marrow cell responsiveness to rsCD23.Entities:
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Year: 1990 PMID： 2140059
Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 22.113