Literature DB >> 21398345

Is there a role for subcutaneous furosemide in the community and hospice management of end-stage heart failure?

Hannah Zacharias1, Janet Raw, Anne Nunn, Sharon Parsons, Miriam Johnson.   

Abstract

Patients with advanced chronic heart failure (CHF) can experience 'revolving door' admissions, often for parenteral diuretics, when time at home is precious. Home intravenous diuretic services are patchy. This retrospective review describes 43 consecutive episodes of continuous subcutaneous infusion of furosemide (CSCI-F) in 32 advanced CHF patients; 28 episodes aiming to correct fluid balance and prevent hospital admission and 15 aiming to prevent symptoms in the dying. Overall, 26/28 (93%) avoided hospital admission. Weight loss occurred in 20/28 (70%): a median loss of 5.6 kg [interquartile range (IQR) 0.1-8.9]). The daily dose of furosemide ranged from 40 to 250 mg. The median number of days on CSCI-F was 10.5 (range 2-48; IQR 6-13.8). Site reactions occurred in 10/43 (23%); all of which were mild except two, one of which required oral antibiotics. Symptoms were controlled in all 15 dying patients. CSCI-F for patients with advanced CHF is effective in terms of weight loss and prevention of hospital admission with the heart failure nurse specialist playing a key overall management role in selection and monitoring. As the majority of community and hospice nurses have access to and are familiar with CSCI pumps, this practice should be nationally transferable. The role in the dying patient requires further assessment.

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Year:  2011        PMID: 21398345     DOI: 10.1177/0269216311399490

Source DB:  PubMed          Journal:  Palliat Med        ISSN: 0269-2163            Impact factor:   4.762


  7 in total

Review 1.  Drug therapy optimization at the end of life.

Authors:  Alfonso J Cruz-Jentoft; Benoit Boland; Lourdes Rexach
Journal:  Drugs Aging       Date:  2012-06-01       Impact factor: 3.923

Review 2.  Subcutaneous furosemide for the treatment of heart failure: a state-of-the art review.

Authors:  Maxwell Eyram Afari; Joe Aoun; Sarthak Khare; Lana Tsao
Journal:  Heart Fail Rev       Date:  2019-05       Impact factor: 4.214

3.  Availability of Heart Failure Medications in Hospice Care.

Authors:  Hillary D Lum; Carolyn Horney; David Koets; Jean S Kutner; Daniel D Matlock
Journal:  Am J Hosp Palliat Care       Date:  2015-08-31       Impact factor: 2.500

4.  Dilemmas in the Dosing of Heart Failure Drugs: Titrating Diuretics in Chronic Heart Failure.

Authors:  David Pham; Justin L Grodin
Journal:  Card Fail Rev       Date:  2017-11

5.  Outpatient Worsening Heart Failure as a Target for Therapy: A Review.

Authors:  Stephen J Greene; Robert J Mentz; G Michael Felker
Journal:  JAMA Cardiol       Date:  2018-03-01       Impact factor: 14.676

6.  Combination therapy with low-dose metolazone and furosemide: a "needleless" approach in managing refractory fluid overload in elderly renal failure patients under palliative care.

Authors:  Hon Wai Benjamin Cheng; Mau-Kwong Sham; Kwok-Ying Chan; Cho-Wing Li; Ho-Yan Au; Terence Yip
Journal:  Int Urol Nephrol       Date:  2014-05-14       Impact factor: 2.370

7.  Subcutaneous Furosemide in Heart Failure: Pharmacokinetic Characteristics of a Newly Buffered Solution.

Authors:  Domenic A Sica; Pieter Muntendam; Rene L Myers; Jozine M Ter Maaten; Mark E Sale; Rudolf A de Boer; Bertram Pitt
Journal:  JACC Basic Transl Sci       Date:  2018-02-07
  7 in total

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