BACKGROUND:Citicoline (cytidine-5'-diphosphate) is a mononucleotide composed of ribose, cytosine, pyrophosphate, and choline, and is involved in the biosynthesis of the structural phosopholipids of cell membranes. Treatment with citicoline, improves memory in patients with dementia, and reduces damage to the brain after traumatic brain injury or stroke. Recent research has been conducted to assess whether citicoline is an effective treatment for cocaine dependence. In cocaine-dependent individuals, withdrawal from cocaine is associated with disturbed sleep, which may contribute to the high rate of relapse to cocaine use. Therefore, it is important to know the impact of citicoline on the sleep/wake cycle in these individuals in order to rate its overall efficacy. METHOD: In this double-blind, placebo-controlled trial, the effects of citicoline treatment on the sleep/wake cycles of cocaine dependent participants were assessed. The results of the current study are reported as part of a larger study, consisting of an eight-week treatment period to assess the efficacy of longer-term treatment with citicoline at decreasing cocaine consumption in cocaine-dependent polydrug using participants. RESULTS: In this non-abstinent, cocaine-dependent population, citicoline had no effect on any of the sleep parameters measured including sleep efficiency, sleep latency, total sleep time, number of waking episodes, time awake per episode, amount of time in bed spent moving, number of sleep episodes, time asleep per episode, and amount of time in bed spent immobile. CONCLUSIONS: These data suggest that eight weeks of citicoline administration does not disturb sleep/wake cycles of cocaine-dependent individuals.
RCT Entities:
BACKGROUND:Citicoline (cytidine-5'-diphosphate) is a mononucleotide composed of ribose, cytosine, pyrophosphate, and choline, and is involved in the biosynthesis of the structural phosopholipids of cell membranes. Treatment with citicoline, improves memory in patients with dementia, and reduces damage to the brain after traumatic brain injury or stroke. Recent research has been conducted to assess whether citicoline is an effective treatment for cocaine dependence. In cocaine-dependent individuals, withdrawal from cocaine is associated with disturbed sleep, which may contribute to the high rate of relapse to cocaine use. Therefore, it is important to know the impact of citicoline on the sleep/wake cycle in these individuals in order to rate its overall efficacy. METHOD: In this double-blind, placebo-controlled trial, the effects of citicoline treatment on the sleep/wake cycles of cocaine dependent participants were assessed. The results of the current study are reported as part of a larger study, consisting of an eight-week treatment period to assess the efficacy of longer-term treatment with citicoline at decreasing cocaine consumption in cocaine-dependent polydrug using participants. RESULTS: In this non-abstinent, cocaine-dependent population, citicoline had no effect on any of the sleep parameters measured including sleep efficiency, sleep latency, total sleep time, number of waking episodes, time awake per episode, amount of time in bed spent moving, number of sleep episodes, time asleep per episode, and amount of time in bed spent immobile. CONCLUSIONS: These data suggest that eight weeks of citicoline administration does not disturb sleep/wake cycles of cocaine-dependent individuals.
Authors: Antoni Dávalos; José Castillo; José Alvarez-Sabín; Julio J Secades; Joan Mercadal; Sonia López; Erik Cobo; Steven Warach; David Sherman; Wayne M Clark; Rafael Lozano Journal: Stroke Date: 2002-12 Impact factor: 7.914
Authors: Stephanie C Licata; David M Penetar; Caitlin Ravichandran; John Rodolico; Christopher Palmer; Jeff Berko; Thomas Geaghan; Alison Looby; Erica Peters; Elizabeth Ryan; Perry F Renshaw; Scott E Lukas Journal: J Addict Med Date: 2011-03 Impact factor: 3.702
Authors: S Warach; L C Pettigrew; J F Dashe; P Pullicino; D M Lefkowitz; L Sabounjian; K Harnett; U Schwiderski; R Gammans Journal: Ann Neurol Date: 2000-11 Impact factor: 10.422
Authors: Brian M Ross; Anna Moszczynska; Frank J Peretti; Vernard Adams; Gregory A Schmunk; Kathryn S Kalasinsky; Lee Ang; Nikolaos Mamalias; Sylvie D Turenne; Stephen J Kish Journal: Drug Alcohol Depend Date: 2002-06-01 Impact factor: 4.492
Authors: Staci A Gruber; Kelly A Sagar; Mary Kathryn Dahlgren; Atilla Gonenç; Nina A Conn; Jeffrey P Winer; David Penetar; Scott E Lukas Journal: Int J Neurol Neurother Date: 2015-09-30