| Literature DB >> 21396980 |
Alejandra E Ruiz-Contreras1, Maribel Delgado-Herrera, Paola A García-Vaca, Georgina A Almeida-Rosas, Gerardo Soria-Rodríguez, Alejandro Soriano-Bautista, Jaime Cadena-Valencia, Jorge R Bazán-Frías, Nardhy Gómez-López, Aurora Espejel-Núñez, Felipe Vadillo-Ortega, Karol Carrillo-Sánchez, Juan C Verdín-Reyes, Santiago March-Mifsut, Mónica Méndez-Díaz, Oscar Prospéro-García.
Abstract
Procedural learning refers to the acquisition of motor skills and the practice that refines their performance. The striatum participates in this learning through a function regulated by endocannabinoid signaling and other systems. This study relates the efficiency in learning a procedural task with the AATn polymorphism of the CNR1 gene, which encodes for the CB1 receptor. The mirror-drawing star task was solved by 99 healthy young subjects in three trials. The sample was divided into high- and low-performance groups based on performance efficiency. AAT12/14 carriers were more frequent in the former group, while there were more AAT12/13 carriers in the latter, which also made more errors/min. Therefore, we characterized two efficiency phenotypes: high- vs. low-performers associated with the two AATn genotypes, AAT12/14 vs. AAT12/13. The findings suggest that AATn polymorphism modifies CNR1 translation, indicating a different modulation of CB1.Entities:
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Year: 2011 PMID： 21396980 DOI： 10.1016/j.neulet.2011.03.013
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046