Literature DB >> 21396422

Critical period exists in the effects of isolation rearing on sensorimotor gating function but not locomotor activity in rat.

Yia-Ping Liu1, Yu-Chen Kao, Che-Se Tung.   

Abstract

Isolation-reared (IR) rats exhibit various cognitive and behavioral abnormalities in adulthood of which locomotor hyperactivity and impaired prepulse inhibition (PPI) of an acoustic startle reflex are the two cardinal characteristics. Using an amended social deprivation-resocialization paradigm, the present study examined the role of the developmental specificity of the effects of IR and its interaction with the non-competitive NMDA receptor antagonist, MK-801. Locomotor activity and PPI were measured in three groups of adult rats: social control, IR throughout life, and IR for the first two weeks after weaning followed by social housing. MK-801 was injected intraperitoneally (i.p.) 30 min prior to testing at doses of 0, 0.02, 0.1, and 0.2 mg/kg. The results revealed that locomotor activity increased only in rats in the IR throughout life group but not in the other two groups. The impairment of PPI was seen in rats in the IR for the first two weeks and the IR throughout life groups. Furthermore, the effect of MK-801 on PPI was bidirectional in rats of the IR for the first two weeks and IR throughout life groups but not in the social control group. These results suggest that the IR-induced behavioral effects are developed distinctively in terms of the critical period hypothesis, which strengthens the developmental hypothesis of schizophrenic-like dysfunctions.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 21396422     DOI: 10.1016/j.pnpbp.2011.03.002

Source DB:  PubMed          Journal:  Prog Neuropsychopharmacol Biol Psychiatry        ISSN: 0278-5846            Impact factor:   5.067


  6 in total

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Journal:  Eur J Neurosci       Date:  2013-01-08       Impact factor: 3.386

Review 2.  Adolescent Social Isolation as a Model of Heightened Vulnerability to Comorbid Alcoholism and Anxiety Disorders.

Authors:  Tracy R Butler; Anushree N Karkhanis; Sara R Jones; Jeffrey L Weiner
Journal:  Alcohol Clin Exp Res       Date:  2016-05-07       Impact factor: 3.455

Review 3.  Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction.

Authors:  Michael J Watt; Matthew A Weber; Shaydel R Davies; Gina L Forster
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2017-06-19       Impact factor: 5.067

4.  'Waiting impulsivity' in isolation-reared and socially-reared rats: effects of amphetamine.

Authors:  Yia-Ping Liu; Lawrence S Wilkinson; Trevor W Robbins
Journal:  Psychopharmacology (Berl)       Date:  2017-03-17       Impact factor: 4.530

Review 5.  Friend of the Devil: Negative Social Influences Driving Substance Use Disorders.

Authors:  Matthew B Pomrenze; Franciely Paliarin; Rajani Maiya
Journal:  Front Behav Neurosci       Date:  2022-02-10       Impact factor: 3.558

6.  Effects of 5HT1A Activation on Gating Profile Following 5HT Depletion in Rats Lacking Social Attachment Since Weanling.

Authors:  Yueh-Ming Tai; Chih-Yuan Ko; Chen-Cheng Lin; Yu-Yue Wan; Jing-Yi Chung; Yia-Ping Liu
Journal:  Psychiatry Investig       Date:  2017-11-07       Impact factor: 2.505

  6 in total

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