BACKGROUND: Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (MRI) can provide information about traumatic changes not visible in conventional MRI. The ADC values in acute traumatic brain injury (TBI) were measured and correlated with initial severity and outcome scores. METHODS: In this study 22 unselected patients were studied 1 week (mean 7 ± 2 days) after TBI of variable severity. In conventional MRI 7 patients were without visible findings, 15 showed cortical contusions or traumatic axonal injury and 14 healthy subjects served as controls. The ADC values were measured from 46 brain regions away from the visible traumatic changes and compared between the groups. Regional ADC values and the number of abnormal regions were correlated with the Glasgow coma scale (GCS) on arrival in hospital and the Glasgow outcome scale (extended version, GOS-E) at 1 year after injury. RESULTS: The ADC values of TBI patients with and without visible lesions did not show any differences but both groups differed significantly from the controls in several cortical and deep brain regions. Increased ADC values were common in TBI groups but decreased ADC values were relatively uncommon. The regional ADC values and the number of abnormal regions did not correlate with either GCS or GOS-E scores. CONCLUSIONS: Increased diffusion in normal appearing brain tissue is a common finding 1 week after TBI in patients with and without visible lesions in conventional MRI. More investigations are needed to evaluate how these findings could be used for clinical applications.
BACKGROUND: Apparent diffusion coefficient (ADC) values derived from diffusion-weighted magnetic resonance imaging (MRI) can provide information about traumatic changes not visible in conventional MRI. The ADC values in acute traumatic brain injury (TBI) were measured and correlated with initial severity and outcome scores. METHODS: In this study 22 unselected patients were studied 1 week (mean 7 ± 2 days) after TBI of variable severity. In conventional MRI 7 patients were without visible findings, 15 showed cortical contusions or traumatic axonal injury and 14 healthy subjects served as controls. The ADC values were measured from 46 brain regions away from the visible traumatic changes and compared between the groups. Regional ADC values and the number of abnormal regions were correlated with the Glasgow coma scale (GCS) on arrival in hospital and the Glasgow outcome scale (extended version, GOS-E) at 1 year after injury. RESULTS: The ADC values of TBI patients with and without visible lesions did not show any differences but both groups differed significantly from the controls in several cortical and deep brain regions. Increased ADC values were common in TBI groups but decreased ADC values were relatively uncommon. The regional ADC values and the number of abnormal regions did not correlate with either GCS or GOS-E scores. CONCLUSIONS: Increased diffusion in normal appearing brain tissue is a common finding 1 week after TBI in patients with and without visible lesions in conventional MRI. More investigations are needed to evaluate how these findings could be used for clinical applications.
Authors: Thierry A G M Huisman; A Gregory Sorensen; Klaus Hergan; R Gilberto Gonzalez; Pamela W Schaefer Journal: J Comput Assist Tomogr Date: 2003 Jan-Feb Impact factor: 1.826
Authors: Pamela W Schaefer; Thierry A G M Huisman; A Gregory Sorensen; R Gilberto Gonzalez; Lee H Schwamm Journal: Radiology Date: 2004-08-10 Impact factor: 11.105
Authors: R L Mittl; R I Grossman; J F Hiehle; R W Hurst; D R Kauder; T A Gennarelli; G W Alburger Journal: AJNR Am J Neuroradiol Date: 1994-09 Impact factor: 3.825
Authors: M E Shenton; H M Hamoda; J S Schneiderman; S Bouix; O Pasternak; Y Rathi; M-A Vu; M P Purohit; K Helmer; I Koerte; A P Lin; C-F Westin; R Kikinis; M Kubicki; R A Stern; R Zafonte Journal: Brain Imaging Behav Date: 2012-06 Impact factor: 3.978