Literature DB >> 21394477

Characterization of the micA gene encoding a small regulatory σE-dependent RNA in Salmonella enterica serovar Typhimurium.

D Homerova1, B Rezuchova, A Stevenson, H Skovierova, M Roberts, J Kormanec.   

Abstract

The role of MicA (repressing small regulatory non-coding RNAs of two Salmonella porins) was determined in virulence of Salmonella enterica serovar Typhimurium. Transcriptional analysis revealed that the expression of the micA gene is driven by a single σ(E)-dependent promoter, micAp. Its activity increased towards stationary phase; in exponential phase, the activity was induced by several stresses by a DegS-dependent mechanism. Although phenotypic analysis revealed no significant differences between wild-type and the micA mutant strains, in vivo studies showed that this mutant is more virulent in the mouse model.

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Year:  2011        PMID： 21394477     DOI： 10.1007/s12223-011-0014-4

Source DB:  PubMed          Journal:  Folia Microbiol (Praha)        ISSN： 0015-5632            Impact factor:   2.099


  22 in total

Review 1.  Analyzing the developmental expression of sigma factors with S1-nuclease mapping.

Authors:  J Kormanec
Journal:  Methods Mol Biol       Date:  2001

Review 2.  Sensing external stress: watchdogs of the Escherichia coli cell envelope.

Authors:  Natividad Ruiz; Thomas J Silhavy
Journal:  Curr Opin Microbiol       Date:  2005-04       Impact factor: 7.934

3.  Conserved small non-coding RNAs that belong to the sigmaE regulon: role in down-regulation of outer membrane proteins.

Authors:  Jesper Johansen; Anders Aamann Rasmussen; Martin Overgaard; Poul Valentin-Hansen
Journal:  J Mol Biol       Date:  2006-09-08       Impact factor: 5.469

4.  Identification of the sigmaE regulon of Salmonella enterica serovar Typhimurium.

Authors:  Henrieta Skovierova; Gary Rowley; Bronislava Rezuchova; Dagmar Homerova; Claire Lewis; Mark Roberts; Jan Kormanec
Journal:  Microbiology       Date:  2006-05       Impact factor: 2.777

5.  Improved vector system for constructing transcriptional fusions that ensures independent translation of lacZ.

Authors:  T Linn; R St Pierre
Journal:  J Bacteriol       Date:  1990-02       Impact factor: 3.490

6.  The alternative sigma factor, sigmaE, is critically important for the virulence of Salmonella typhimurium.

Authors:  S Humphreys; A Stevenson; A Bacon; A B Weinhardt; M Roberts
Journal:  Infect Immun       Date:  1999-04       Impact factor: 3.441

7.  Small outer-membrane lipoprotein, SmpA, is regulated by sigmaE and has a role in cell envelope integrity and virulence of Salmonella enterica serovar Typhimurium.

Authors:  Claire Lewis; Henrieta Skovierova; Gary Rowley; Bronislava Rezuchova; Dagmar Homerova; Andrew Stevenson; Aileen Sherry; Jan Kormanec; Mark Roberts
Journal:  Microbiology       Date:  2008-03       Impact factor: 2.777

8.  Gene disruption in Escherichia coli: TcR and KmR cassettes with the option of Flp-catalyzed excision of the antibiotic-resistance determinant.

Authors:  P P Cherepanov; W Wackernagel
Journal:  Gene       Date:  1995-05-26       Impact factor: 3.688

9.  Sigma E controls biogenesis of the antisense RNA MicA.

Authors:  Klas I Udekwu; E Gerhart H Wagner
Journal:  Nucleic Acids Res       Date:  2007-01-31       Impact factor: 16.971

10.  SigmaE-dependent small RNAs of Salmonella respond to membrane stress by accelerating global omp mRNA decay.

Authors:  Kai Papenfort; Verena Pfeiffer; Franziska Mika; Sacha Lucchini; Jay C D Hinton; Jörg Vogel
Journal:  Mol Microbiol       Date:  2006-12       Impact factor: 3.501
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  1 in total

Review 1.  Experimental approaches to identify small RNAs and their diverse roles in bacteria--what we have learnt in one decade of MicA research.

Authors:  Sandra Van Puyvelde; Jozef Vanderleyden; Sigrid C J De Keersmaecker
Journal:  Microbiologyopen       Date:  2015-05-13       Impact factor: 3.139
  1 in total

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