Literature DB >> 21393060

5-HT and the immune system.

Gerard P Ahern1.   

Abstract

The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21393060      PMCID： PMC3144148          DOI： 10.1016/j.coph.2011.02.004

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  24 in total

1.  5-HT(1B) receptors play a prominent role in the proliferation of T-lymphocytes.

Authors:  Jun Yin; Ross H Albert; Anna P Tretiakova; Bradford A Jameson
Journal:  J Neuroimmunol       Date:  2006-10-02       Impact factor: 3.478

2.  Human mast cells are capable of serotonin synthesis and release.

Authors:  Nataliya M Kushnir-Sukhov; Jared M Brown; Yalin Wu; Arnold Kirshenbaum; Dean D Metcalfe
Journal:  J Allergy Clin Immunol       Date:  2006-10-13       Impact factor: 10.793

3.  Induction of indefinite survival of fully mismatched cardiac allografts and generation of regulatory cells by sarpogrelate hydrochloride.

Authors:  Takurin Akiyoshi; Qi Zhang; Fumihiko Inoue; Osamu Aramaki; Minoru Hatano; Motohide Shimazu; Masaki Kitajima; Nozomu Shirasugi; Masanori Niimi
Journal:  Transplantation       Date:  2006-10-27       Impact factor: 4.939

4.  5-hydroxytryptamine induces mast cell adhesion and migration.

Authors:  Nataliya M Kushnir-Sukhov; Alasdair M Gilfillan; John W Coleman; Jared M Brown; Sandra Bruening; Miklos Toth; Dean D Metcalfe
Journal:  J Immunol       Date:  2006-11-01       Impact factor: 5.422

5.  Effect of serotonin on the differentiation of human monocytes into dendritic cells.

Authors:  N Katoh; F Soga; T Nara; R Tamagawa-Mineoka; M Nin; H Kotani; K Masuda; S Kishimoto
Journal:  Clin Exp Immunol       Date:  2006-11       Impact factor: 4.330

6.  A novel form of immune signaling revealed by transmission of the inflammatory mediator serotonin between dendritic cells and T cells.

Authors:  Peta J O'Connell; Xiangbin Wang; Matilde Leon-Ponte; Corrie Griffiths; Sandeep C Pingle; Gerard P Ahern
Journal:  Blood       Date:  2005-10-13       Impact factor: 22.113

7.  The serotonin transporter (SLC6A4) is present in B-cell clones of diverse malignant origin: probing a potential anti-tumor target for psychotropics.

Authors:  Elizabeth J Meredith; Michelle J Holder; Anita Chamba; Anita Challa; Adrian Drake-Lee; Christopher M Bunce; Mark T Drayson; Geoffrey Pilkington; Randy D Blakely; Martin J S Dyer; Nicholas M Barnes; John Gordon
Journal:  FASEB J       Date:  2005-05-03       Impact factor: 5.191

8.  Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells.

Authors:  Adamantios Serafeim; Michelle J Holder; Gillian Grafton; Anita Chamba; Mark T Drayson; Quang T Luong; Christopher M Bunce; Christopher D Gregory; Nicholas M Barnes; John Gordon
Journal:  Blood       Date:  2002-12-19       Impact factor: 22.113

9.  The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release.

Authors:  Marco Idzko; Elisabeth Panther; Christian Stratz; Tobias Müller; Hannes Bayer; Gernot Zissel; Thorsten Dürk; Stephan Sorichter; Francesco Di Virgilio; Michael Geissler; Bernd Fiebich; Yared Herouy; Peter Elsner; Johannes Norgauer; Davide Ferrari
Journal:  J Immunol       Date:  2004-05-15       Impact factor: 5.422

10.  In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma.

Authors:  Leonie S van Rijt; Steffen Jung; Alex Kleinjan; Nanda Vos; Monique Willart; Catherine Duez; Henk C Hoogsteden; Bart N Lambrecht
Journal:  J Exp Med       Date:  2005-03-21       Impact factor: 14.307
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  73 in total

1.  Prolonged stimulation of a brainstem raphe region attenuates experimental autoimmune encephalomyelitis.

Authors:  Pernille M Madsen; Stephanie S Sloley; Alberto A Vitores; Melissa M Carballosa-Gautam; Roberta Brambilla; Ian D Hentall
Journal:  Neuroscience       Date:  2017-01-29       Impact factor: 3.590

Review 2.  Contributions of nonhematopoietic cells and mediators to immune responses: implications for immunotoxicology.

Authors:  Barbara L F Kaplan; Jinze Li; John J LaPres; Stephen B Pruett; Peer W F Karmaus
Journal:  Toxicol Sci       Date:  2015-06       Impact factor: 4.849

Review 3.  Mast Cell Serotonin Immunoregulatory Effects Impacting on Neuronal Function: Implications for Neurodegenerative and Psychiatric Disorders.

Authors:  P Conti; Y B Shaik-Dasthagirisaheb
Journal:  Neurotox Res       Date:  2015-06-03       Impact factor: 3.911

4.  The distribution and chemical coding of enteroendocrine cells in Trypanosoma cruzi-infected individuals with chagasic megacolon.

Authors:  Patrícia Rocha Martins; Josiane Fakhry; Adriana Jacaúna de Oliveira; Thayse Batista Moreira; Linda J Fothergill; Enio Chaves de Oliveira; Débora d'Ávila Reis; John B Furness
Journal:  Histochem Cell Biol       Date:  2021-01-06       Impact factor: 4.304

Review 5.  Update in asthma 2013.

Authors:  Lauren Cohn; Prescott G Woodruff
Journal:  Am J Respir Crit Care Med       Date:  2014-06-15       Impact factor: 21.405

Review 6.  Interactions between the microbiota, immune and nervous systems in health and disease.

Authors:  Thomas C Fung; Christine A Olson; Elaine Y Hsiao
Journal:  Nat Neurosci       Date:  2017-01-16       Impact factor: 24.884

7.  CD4 T cells differentially express cellular machinery for serotonin signaling, synthesis, and metabolism.

Authors:  Hera Wu; DeVon Herr; Nancie J MacIver; Jeffrey C Rathmell; Valerie A Gerriets
Journal:  Int Immunopharmacol       Date:  2020-08-28       Impact factor: 4.932

Review 8.  5-Hydroxytryptamine (serotonin) in the gastrointestinal tract.

Authors:  Michael D Gershon
Journal:  Curr Opin Endocrinol Diabetes Obes       Date:  2013-02       Impact factor: 3.243

Review 9.  A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity.

Authors:  Ede Frecska; Attila Szabo; Michael J Winkelman; Luis E Luna; Dennis J McKenna
Journal:  J Neural Transm (Vienna)       Date:  2013-04-26       Impact factor: 3.575

Review 10.  A dialogue between the immune system and brain, spoken in the language of serotonin.

Authors:  Nicole L Baganz; Randy D Blakely
Journal:  ACS Chem Neurosci       Date:  2012-12-07       Impact factor: 4.418
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