| Literature DB >> 21392988 |
Darin J Gustin1, Zhihua Ma, Xiaoshan Min, Yihong Li, Christine Hedberg, Cris Guimaraes, Amy C Porter, Michelle Lindstrom, Dianna Lester-Zeiner, Guifen Xu, Timothy J Carlson, Shouhua Xiao, Cesar Meleza, Richard Connors, Zhulun Wang, Frank Kayser.
Abstract
Starting from a series of ureas that were determined to be mechanism-based inhibitors of FAAH, several spirocyclic ureas and lactams were designed and synthesized. These efforts identified a series of novel, noncovalent FAAH inhibitors with in vitro potency comparable to known covalent FAAH inhibitors. The mechanism of action for these compounds was determined through a combination of SAR and co-crystallography with rat FAAH.Entities:
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Year: 2011 PMID： 21392988 DOI： 10.1016/j.bmcl.2011.02.052
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823