| Literature DB >> 2139258 |
M P Lisanti1, E Rodriguez-Boulan.
Abstract
The sorting signals that guide proteins to apical and basolateral surfaces of epithelial cells have remained elusive. Current evidence suggests a hierarchy of sorting information with multiple sorting signals (apical and basolateral) present in different domains of a given plasma membrane protein. The observation that covalently attached glycosyl-phosphatidylinositol (GPI) acts as a 'dominant' apical targeting signal is compatible with the involvement of glycolipids in epithelial protein sorting.Entities:
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Year: 1990 PMID: 2139258 DOI: 10.1016/0968-0004(90)90195-h
Source DB: PubMed Journal: Trends Biochem Sci ISSN: 0968-0004 Impact factor: 13.807