Literature DB >> 21392488

Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009-2011.

G C Mak1, C K Leung, K C Cheng, K Y Wong, W Lim.   

Abstract

Phylogenetic analysis of the haemagglutinin (HA) gene shows that the influenza A(H1N1)2009 viruses collected in Hong Kong clustered in two main branches characterised by the E391E and E391K amino acids. The main branch E391K evolved in two sub-branches with N142D and S202T mutations that first appeared in March and July 2010, respectively, with the latter becoming the predominant strain. These genetic variants that emerged display similar antigenic characteristics.Concurrent with genetic surveillance, laboratories should continue monitoring the circulating viruses antigenically.

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Year:  2011        PMID： 21392488

Source DB:  PubMed          Journal:  Euro Surveill        ISSN： 1025-496X


  8 in total

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4.  Amino acid substitutions in hemagglutinin of the 2009 pandemic influenza A(H1N1) viruses that might affect the viral antigenicity.

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Authors:  Christopher R Cotter; Hong Jin; Zhongying Chen
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  8 in total

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