BACKGROUND: Topiramate has been recognized as a drug that can induce memory and cognitive impairment. Using the one-trial inhibitory avoidance task, we sought to verify the effect of topiramate on consolidation and extinction of aversive memory. Our hypothesis was that topiramate inhibits the consolidation and enhances the extinction of this fear memory. METHODS: In experiment 1, which occured immediately or 3 hours after training, topiramate was administered to rats, and consolidation of memory was verified 18 days after the conditioning session. In experiment 2, which occured 18-22 days after the training session, rats were submitted to the extinction protocol. Rats received topiramate 14 days before or during the extinction protocol. RESULTS: Topiramate blocked fear memory retention (p < 0.01) and enhanced fear memory extinction (p < 0.001) only when administered during the extinction protocol. LIMITATIONS: This experimental design did not allow us to determine whether topiramate also blocked the reconsolidation of fear memory. CONCLUSION: Topira mate diminishes fear memory consolidation and promotes extinction of inhibitory avoidance memory.
BACKGROUND:Topiramate has been recognized as a drug that can induce memory and cognitive impairment. Using the one-trial inhibitory avoidance task, we sought to verify the effect of topiramate on consolidation and extinction of aversive memory. Our hypothesis was that topiramate inhibits the consolidation and enhances the extinction of this fear memory. METHODS: In experiment 1, which occured immediately or 3 hours after training, topiramate was administered to rats, and consolidation of memory was verified 18 days after the conditioning session. In experiment 2, which occured 18-22 days after the training session, rats were submitted to the extinction protocol. Rats received topiramate 14 days before or during the extinction protocol. RESULTS:Topiramate blocked fear memory retention (p < 0.01) and enhanced fear memory extinction (p < 0.001) only when administered during the extinction protocol. LIMITATIONS: This experimental design did not allow us to determine whether topiramate also blocked the reconsolidation of fear memory. CONCLUSION: Topira mate diminishes fear memory consolidation and promotes extinction of inhibitory avoidance memory.
Authors: D M Barros; L A Izquierdo; T Mello e Souza; P G Ardenghi; P Pereira; J H Medina; I Izquierdo Journal: Behav Brain Res Date: 2000-09 Impact factor: 3.332
Authors: Bankole A Johnson; Nassima Ait-Daoud; Charles L Bowden; Carlo C DiClemente; John D Roache; Kevin Lawson; Martin A Javors; Jennie Z Ma Journal: Lancet Date: 2003-05-17 Impact factor: 79.321
Authors: Rose Mary Carvalho Pinheiro; Maria Noêmia Martins de Lima; Bernardo Chaves Dávila Portal; Stefano Boemler Busato; Lucio Falavigna; Rafael Dal Ponte Ferreira; André Contri Paz; Bianca Wollenhaupt de Aguiar; Flávio Kapczinski; Nadja Schröder Journal: J Neural Transm (Vienna) Date: 2014-09-03 Impact factor: 3.575