Literature DB >> 21391865

Low-density lipoprotein receptor-related protein 1: new functions for an old molecule.

Massimo Franchini1, Martina Montagnana.   

Abstract

The low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor member of the low-density lipoprotein (LDL)-receptor family. As LRP1 plays an important role in endocytosis and regulation of signalling pathways, it is implicated in a number of physiologic processes, including the regulation of lipid metabolism, the proliferation of vascular smooth muscle cells and in neuro-development. More recently, LRP1 has been implicated in the catabolism of factor VIII and regulation of its plasma concentrations. The pathophysiology of the role of LRP1 in hemostasis will be summarized in this review.

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Year:  2011        PMID： 21391865     DOI： 10.1515/CCLM.2011.154

Source DB:  PubMed          Journal:  Clin Chem Lab Med        ISSN： 1434-6621            Impact factor:   3.694


  12 in total

1.  Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity.

Authors:  Nicole Gudleski-O'Regan; Todd M Greco; Ileana M Cristea; Thomas Shenk
Journal:  Cell Host Microbe       Date:  2012-07-19       Impact factor: 21.023

2.  Regulatory B Cells Are Functionally Impaired in Patients Having Hemophilia A With Inhibitors.

Authors:  Mohamed-Rachid Boulassel; Maryam Al-Ghonimi; Badriya Al-Balushi; Amal Al-Naamani; Zahra Al-Qarni; Yasser Wali; Mohamed Elshinawy; Maryam Al-Shezawi; Hamad Khan; Hanan Nazir; Doaa Khater; Anil Pathare; Salam Al-Kindi
Journal:  Clin Appl Thromb Hemost       Date:  2017-04-10       Impact factor: 2.389

3.  Immunohistochemical localization of low density lipoprotein (LDL) receptor-related protein-1 (LRP1) in the endometrium of cyclic and pregnant pigs.

Authors:  Martin Steffl; Markus Schweiger; Werner M Amselgruber
Journal:  J Mol Histol       Date:  2012-12-09       Impact factor: 2.611

4.  Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts.

Authors:  Thomas S Lisse; Rene F Chun; Sandra Rieger; John S Adams; Martin Hewison
Journal:  J Bone Miner Res       Date:  2013-06       Impact factor: 6.741

Review 5.  Low-density lipoprotein receptor (LDLR) family orchestrates cholesterol homeostasis.

Authors:  Gwang-Woong Go; Arya Mani
Journal:  Yale J Biol Med       Date:  2012-03-29

6.  The LRP1 Gene Polymorphism is associated with Increased Risk of Metabolic Syndrome Prevalence in the Serbian Population.

Authors:  N Vučinić; E Stokić; I Djan; D Obreht; N Veličković; K Stankov; M Djan
Journal:  Balkan J Med Genet       Date:  2017-06-30       Impact factor: 0.519

7.  Yes-Associated Protein (YAP) Promotes Tumorigenesis in Melanoma Cells Through Stimulation of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1).

Authors:  Huizi Xiong; Qian Yu; Yu Gong; Wenjuan Chen; Yunlei Tong; Yao Wang; Hui Xu; Yuling Shi
Journal:  Sci Rep       Date:  2017-11-14       Impact factor: 4.379

8.  Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction.

Authors:  Stefano Toldo; Dana Austin; Adolfo G Mauro; Eleonora Mezzaroma; Benjamin W Van Tassell; Carlo Marchetti; Salvatore Carbone; Soren Mogelsvang; Cohava Gelber; Antonio Abbate
Journal:  JACC Basic Transl Sci       Date:  2017-10-30

9.  Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1).

Authors:  Maryssa Canuel; Xiaowei Sun; Marie-Claude Asselin; Eustache Paramithiotis; Annik Prat; Nabil G Seidah
Journal:  PLoS One       Date:  2013-05-13       Impact factor: 3.240

10.  KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae.

Authors:  Yoshimitsu Kanai; Daliang Wang; Nobutaka Hirokawa
Journal:  J Cell Biol       Date:  2014-01-27       Impact factor: 10.539
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