Literature DB >> 21391701

Vilsmeier reaction of 3-aminopropenamides: one-pot synthesis of pyrimidin-4(3H)-ones.

Rui Zhang1, Dingyuan Zhang, Yongjiu Liang, Guangyuan Zhou, Dewen Dong.   

Abstract

A facile one-pot synthesis of pyrimidin-4(3H)-ones was developed via reactions of a series of readily available 3-aminopropenamides with varied Vilsmeier reagents, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21391701     DOI： 10.1021/jo101949y

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis of pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones: Rearrangement of pyrrolo[1,2-d][1,3,4]oxadiazines and regioselective intramolecular cyclization of 1,2-biscarbamoyl-substituted 1H-pyrroles.

Authors:  Kkonnip Son; Seong Jun Park
Journal:  Beilstein J Org Chem       Date:  2016-08-09       Impact factor: 2.883

2.  An efficient method for the construction of polysubstituted 4-pyridones via self-condensation of β-keto amides mediated by P2O5 and catalyzed by zinc bromide.

Authors:  Liquan Tan; Peng Zhou; Cui Chen; Weibing Liu
Journal:  Beilstein J Org Chem       Date:  2013-11-28       Impact factor: 2.883
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.