Literature DB >> 21391618

A microwave-assisted diastereoselective multicomponent reaction to access dibenzo[c,e]azepinones: synthesis and biological evaluation.

Vaibhav P Mehta1, Sachin G Modha, Eelco Ruijter, Kristof Van Hecke, Luc Van Meervelt, Christophe Pannecouque, Jan Balzarini, Romano V A Orru, Erik Van der Eycken.   

Abstract

An unprecedented microwave-assisted multicomponent strategy has been elaborated for the fast, efficient, and diastereoselective generation of the dibenzo[c,e]azepinone scaffold. The generated compounds were evaluated for their bioactivity.

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Year:  2011        PMID： 21391618     DOI： 10.1021/jo200251q

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  5 in total

1.  Ugi/aldol sequence: expeditious entry to several families of densely substituted nitrogen heterocycles.

Authors:  Zhigang Xu; Fabio De Moliner; Alexandra P Cappelli; Christopher Hulme
Journal:  Angew Chem Int Ed Engl       Date:  2012-06-29       Impact factor: 15.336

2.  Post-Ugi gold-catalyzed diastereoselective domino cyclization for the synthesis of diversely substituted spiroindolines.

Authors:  Amit Kumar; Dipak D Vachhani; Sachin G Modha; Sunil K Sharma; Virinder S Parmar; Erik V Van der Eycken
Journal:  Beilstein J Org Chem       Date:  2013-10-14       Impact factor: 2.883

3.  Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids.

Authors:  Răzvan C Cioc; Verónica Estévez; Daan J van der Niet; Christophe M L Vande Velde; Nikolaus G Turrini; Mélanie Hall; Kurt Faber; Eelco Ruijter; Romano V A Orru
Journal:  European J Org Chem       Date:  2017-03-08

Review 4.  Microwave-assisted multicomponent reactions in heterocyclic chemistry and mechanistic aspects.

Authors:  Shivani Gulati; Stephy Elza John; Nagula Shankaraiah
Journal:  Beilstein J Org Chem       Date:  2021-04-19       Impact factor: 2.883

5.  One-pot Ugi/Aza-Michael synthesis of highly substituted 2,5-diketopiperazines with anti-proliferative properties.

Authors:  Andreas Hartung; Florian Seufert; Carsten Berges; Viktoria H Gessner; Ulrike Holzgrabe
Journal:  Molecules       Date:  2012-12-11       Impact factor: 4.411
  5 in total

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