Literature DB >> 21391472

The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS).

J Wassell1, M Michail, N Soliman, P G Wardle.   

Abstract

BACKGROUND: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterised by chronic anovulation, hyperandrogenism and polycystic ovaries on ultrasound. Patients commonly show features of the metabolic syndrome and insulin resistance. It has been shown that treatment with the insulin sensitising agent metformin can lead to improvements in symptoms in some but not all patients. The aim of the study was to assess whether sex hormone binding globulin (SHBG) (a surrogate marker of insulin resistance) could predict a positive response to metformin treatment in women with PCOS.
METHODS: Medical notes of patients who presented to the gynaecology clinic at Southmead Hospital, Bristol with suspected PCOS were reviewed. Data collected included clinical symptoms and signs of hyperandrogenism, markers of PCOS in the family and obstetric history, biochemical markers and outcome of any treatment.
RESULTS: A total of 66 patients were included in the study; 45 were classified as PCOS positive. In this group, patients who responded to metformin treatment had significantly lower SHBG levels compared to those who did not (median SHBG 37.5 nmol/L compared to 56.0 nmol/L) (p = 0.016, Mann-Whitney U-test). Patients with lower SHBG tended to have a better treatment outcome than those with higher values (odds ratio 0.983, 95% confidence interval 0.963-1.002, p = 0.079).
CONCLUSIONS: Patients with a positive response to metformin treatment had significantly lower pre-treatment SHBG levels. For every unit increase in SHBG, the odds of a patient having a positive outcome to metformin treatment fell by a factor of 0.983.

Entities:  

Mesh:

Substances:

Year:  2011        PMID: 21391472

Source DB:  PubMed          Journal:  Clin Lab        ISSN: 1433-6510            Impact factor:   1.138


  4 in total

1.  RS1799817 in INSR associates with susceptibility to polycystic ovary syndrome.

Authors:  Maha H Daghestani
Journal:  J Med Biochem       Date:  2020-01-23       Impact factor: 3.402

2.  A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.

Authors:  Andrea D Coviello; Robin Haring; Melissa Wellons; Dhananjay Vaidya; Terho Lehtimäki; Sarah Keildson; Kathryn L Lunetta; Chunyan He; Myriam Fornage; Vasiliki Lagou; Massimo Mangino; N Charlotte Onland-Moret; Brian Chen; Joel Eriksson; Melissa Garcia; Yong Mei Liu; Annemarie Koster; Kurt Lohman; Leo-Pekka Lyytikäinen; Ann-Kristin Petersen; Jennifer Prescott; Lisette Stolk; Liesbeth Vandenput; Andrew R Wood; Wei Vivian Zhuang; Aimo Ruokonen; Anna-Liisa Hartikainen; Anneli Pouta; Stefania Bandinelli; Reiner Biffar; Georg Brabant; David G Cox; Yuhui Chen; Steven Cummings; Luigi Ferrucci; Marc J Gunter; Susan E Hankinson; Hannu Martikainen; Albert Hofman; Georg Homuth; Thomas Illig; John-Olov Jansson; Andrew D Johnson; David Karasik; Magnus Karlsson; Johannes Kettunen; Douglas P Kiel; Peter Kraft; Jingmin Liu; Östen Ljunggren; Mattias Lorentzon; Marcello Maggio; Marcello R P Markus; Dan Mellström; Iva Miljkovic; Daniel Mirel; Sarah Nelson; Laure Morin Papunen; Petra H M Peeters; Inga Prokopenko; Leslie Raffel; Martin Reincke; Alex P Reiner; Kathryn Rexrode; Fernando Rivadeneira; Stephen M Schwartz; David Siscovick; Nicole Soranzo; Doris Stöckl; Shelley Tworoger; André G Uitterlinden; Carla H van Gils; Ramachandran S Vasan; H-Erich Wichmann; Guangju Zhai; Shalender Bhasin; Martin Bidlingmaier; Stephen J Chanock; Immaculata De Vivo; Tamara B Harris; David J Hunter; Mika Kähönen; Simin Liu; Pamela Ouyang; Tim D Spector; Yvonne T van der Schouw; Jorma Viikari; Henri Wallaschofski; Mark I McCarthy; Timothy M Frayling; Anna Murray; Steve Franks; Marjo-Riitta Järvelin; Frank H de Jong; Olli Raitakari; Alexander Teumer; Claes Ohlsson; Joanne M Murabito; John R B Perry
Journal:  PLoS Genet       Date:  2012-07-19       Impact factor: 5.917

3.  Comparative analysis of serum proteome in congenital scoliosis patients with TBX6 haploinsufficiency - a first report pointing to lipid metabolism.

Authors:  Qiankun Zhu; Nan Wu; Gang Liu; Yangzhong Zhou; Sen Liu; Jun Chen; Jiaqi Liu; Yuzhi Zuo; Zhenlei Liu; Weisheng Chen; Yixin Chen; Jia Chen; Mao Lin; Yanxue Zhao; Yang Yang; Shensgru Wang; Xu Yang; Yufen Ma; Jian Wang; Xiaoli Chen; Jianguo Zhang; Jianxiong Shen; Zhihong Wu; Guixing Qiu
Journal:  J Cell Mol Med       Date:  2017-09-25       Impact factor: 5.310

Review 4.  Improvement Effect of Metformin on Female and Male Reproduction in Endocrine Pathologies and Its Mechanisms.

Authors:  Alexander O Shpakov
Journal:  Pharmaceuticals (Basel)       Date:  2021-01-08
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.