Literature DB >> 21389262

Dissecting the immune cell mayhem that drives lupus pathogenesis.

Joseph E Craft1.   

Abstract

The autoimmune disease systemic lupus erythematosus (SLE) results from an inability of the immune system to discriminate between certain self-antigens and foreign ones. The most common treatment of SLE involves the use of immunosuppressive drugs to reduce inflammation, but these therapies have serious side effects. Three recent papers in Science Translational Medicine redirect focus on neutrophils, platelets, and interferon-α in the pathogenesis of SLE and reinforce the notion that researchers should seek to discover and devise combination therapies that target these processes.

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Year:  2011        PMID： 21389262      PMCID： PMC3694130          DOI： 10.1126/scitranslmed.3002138

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN： 1946-6234            Impact factor:   17.956


  40 in total

1.  Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells.

Authors:  A Krug; S Rothenfusser; V Hornung; B Jahrsdörfer; S Blackwell; Z K Ballas; S Endres; A M Krieg; G Hartmann
Journal:  Eur J Immunol       Date:  2001-07       Impact factor: 5.532

Review 2.  From T to B and back again: positive feedback in systemic autoimmune disease.

Authors:  M J Shlomchik; J E Craft; M J Mamula
Journal:  Nat Rev Immunol       Date:  2001-11       Impact factor: 53.106

3.  Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

Authors:  P Blanco; A K Palucka; M Gill; V Pascual; J Banchereau
Journal:  Science       Date:  2001-11-16       Impact factor: 47.728

4.  A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus.

Authors:  L A DeGiorgio; K N Konstantinov; S C Lee; J A Hardin; B T Volpe; B Diamond
Journal:  Nat Med       Date:  2001-11       Impact factor: 53.440

5.  Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells.

Authors:  M Bauer; V Redecke; J W Ellwart; B Scherer; J P Kremer; H Wagner; G B Lipford
Journal:  J Immunol       Date:  2001-04-15       Impact factor: 5.422

6.  Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies.

Authors:  A A Bengtsson; G Sturfelt; L Truedsson; J Blomberg; G Alm; H Vallin; L Rönnblom
Journal:  Lupus       Date:  2000       Impact factor: 2.911

7.  Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus.

Authors:  Gina S Garcia-Romo; Simone Caielli; Barbara Vega; John Connolly; Florence Allantaz; Zhaohui Xu; Marilynn Punaro; Jeanine Baisch; Cristiana Guiducci; Robert L Coffman; Franck J Barrat; Jacques Banchereau; Virginia Pascual
Journal:  Sci Transl Med       Date:  2011-03-09       Impact factor: 17.956

8.  Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus.

Authors:  Roberto Lande; Dipyaman Ganguly; Valeria Facchinetti; Loredana Frasca; Curdin Conrad; Josh Gregorio; Stephan Meller; Georgios Chamilos; Rosalie Sebasigari; Valeria Riccieri; Roland Bassett; Hideki Amuro; Shirou Fukuhara; Tomoki Ito; Yong-Jun Liu; Michel Gilliet
Journal:  Sci Transl Med       Date:  2011-03-09       Impact factor: 17.956

9.  Increased circulating platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis.

Authors:  J E Joseph; P Harrison; I J Mackie; D A Isenberg; S J Machin
Journal:  Br J Haematol       Date:  2001-11       Impact factor: 6.998

10.  Stochastic control of anti-Sm autoantibodies in MRL/Mp-lpr/lpr mice.

Authors:  R A Eisenberg; S Y Craven; R W Warren; P L Cohen
Journal:  J Clin Invest       Date:  1987-09       Impact factor: 14.808
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  19 in total

1.  Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.

Authors:  Uma Sriram; Linda Varghese; Heather L Bennett; Neelakshi R Jog; Debra K Shivers; Yue Ning; Edward M Behrens; Roberto Caricchio; Stefania Gallucci
Journal:  J Immunol       Date:  2012-06-01       Impact factor: 5.422

2.  Suppression of systemic autoimmunity by the innate immune adaptor STING.

Authors:  Shruti Sharma; Allison M Campbell; Jennie Chan; Stefan A Schattgen; Gregory M Orlowski; Ribhu Nayar; Annie H Huyler; Kerstin Nündel; Chandra Mohan; Leslie J Berg; Mark J Shlomchik; Ann Marshak-Rothstein; Katherine A Fitzgerald
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-02       Impact factor: 11.205

Review 3.  Re-Examining Neutrophil Participation in GN.

Authors:  Dawn J Caster; David W Powell; Irina Miralda; Richard A Ward; Kenneth R McLeish
Journal:  J Am Soc Nephrol       Date:  2017-06-15       Impact factor: 10.121

Review 4.  Galectin-3 in autoimmunity and autoimmune diseases.

Authors:  Felipe L de Oliveira; Mariele Gatto; Nicola Bassi; Roberto Luisetto; Anna Ghirardello; Leonardo Punzi; Andrea Doria
Journal:  Exp Biol Med (Maywood)       Date:  2015-07-03

5.  Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.

Authors:  Hongbing Zhang; Lily I Pao; Aileen Zhou; Arthur D Brace; Robert Halenbeck; Amy W Hsu; Thomas L Bray; Kevin Hestir; Elizabeth Bosch; Ernestine Lee; Gang Wang; Haixia Liu; Brian R Wong; W Michael Kavanaugh; Lewis T Williams
Journal:  Proc Natl Acad Sci U S A       Date:  2014-10-20       Impact factor: 11.205

Review 6.  Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?

Authors:  Sudesh Pawaria; Shruti Sharma; Rebecca Baum; Kerstin Nündel; Patricia Busto; Ellen M Gravallese; Katherine A Fitzgerald; Ann Marshak-Rothstein
Journal:  J Leukoc Biol       Date:  2016-08-16       Impact factor: 4.962

Review 7.  Utilization of Biomarkers in Lupus Nephritis.

Authors:  Dawn J Caster; David W Powell
Journal:  Adv Chronic Kidney Dis       Date:  2019-09       Impact factor: 3.620

8.  Types of DNA methylation status of the interspersed repetitive sequences for LINE-1, Alu, HERV-E and HERV-K in the neutrophils from systemic lupus erythematosus patients and healthy controls.

Authors:  Patadon Sukapan; Paramate Promnarate; Yingyos Avihingsanon; Apiwat Mutirangura; Nattiya Hirankarn
Journal:  J Hum Genet       Date:  2014-01-16       Impact factor: 3.172

Review 9.  Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation.

Authors:  Mélanie Souyris; José E Mejía; Julie Chaumeil; Jean-Charles Guéry
Journal:  Semin Immunopathol       Date:  2018-10-01       Impact factor: 9.623

10.  NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.

Authors:  Allison M Campbell; Michael Kashgarian; Mark J Shlomchik
Journal:  Sci Transl Med       Date:  2012-10-24       Impact factor: 17.956
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