| Literature DB >> 21388646 |
Yi-Chun Lai1, Chien-Kuang Chen, Wan-Wan Lin, Shoei-Sheng Lee.
Abstract
This study was aimed to investigate thoroughly the diarylheptanoids in the n-BuOH soluble fraction of leaves of Alnus formosana in order to examine their anti-inflammatory activities. The application of HPLC-SPE-NMR as a preliminary chemical screening led to characterization of eleven compounds. Further separation resulted in isolation of 28 compounds, of which 10 diarylheptanoids and 2-coumaroylxyloside are new natural products. Compound 1 and alnuside A (27) were found to possess good activities against LPS-induced NO production with respective IC(50) values of 7.99 and 8.08 μM, and which were devoid of significant cytotoxicity.Entities:
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Year: 2011 PMID： 21388646 DOI： 10.1016/j.phytochem.2011.02.008
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072