AIMS AND BACKGROUND: The objective of this case-control study was to test the existing hypotheses about factors related to the occurrence of hepatocellular carcinoma in the population of Belgrade (Serbia). METHODS AND STUDY DESIGN: The investigation was conducted between 2004 and 2007 and consisted of 45 newly diagnosed, histologically confirmed hepatocellular carcinoma patients and 90 individually gender- and age-matched hospital controls. Conditional univariate and multivariate logistic regression analyses were applied. RESULTS: A highly statistically significant association (P = 0.001) was demonstrated between hepatocellular carcinoma and HBsAg positivity and the presence of hepatitis C virus antibodies. Diabetes mellitus was significantly (P = 0.018) associated with an increased risk of hepatocellular carcinoma. A statistically significant inverse association was shown between low parity and the risk of hepatocellular carcinoma (P = 0.033). The risk increased significantly with a longer history of cigarette smoking (P = 0.044), as well as the daily consumption of hard liquor (P = 0.049). A weekly intake of fish (P = 0.003) and yogurt (P = 0.003) and daily intake of boiled vegetables (P = 0.001) were reported more frequently by controls than hepatocellular carcinoma cases. In the current study, a high intake of salty food also significantly increased the risk of hepatocellular carcinoma (P = 0.027). Based on multivariate analysis, the presence of hepatitis C virus antibodies (OR = 24.6, P = 0.001) and duration of smoking > or =25 years (OR = 3.8, P = 0.020) were significantly related to hepatocellular carcinoma, whereas the daily consumption of boiled vegetables (OR = 0.1, P = 0.011) was inversely associated with the risk of hepatocellular carcinoma. CONCLUSIONS: The findings obtained in the current study support the hypotheses that non-viral factors, such as lifestyle factors, reproductive factors, and a history of diabetes, might be involved in the etiology of hepatocellular carcinoma.
AIMS AND BACKGROUND: The objective of this case-control study was to test the existing hypotheses about factors related to the occurrence of hepatocellular carcinoma in the population of Belgrade (Serbia). METHODS AND STUDY DESIGN: The investigation was conducted between 2004 and 2007 and consisted of 45 newly diagnosed, histologically confirmed hepatocellular carcinomapatients and 90 individually gender- and age-matched hospital controls. Conditional univariate and multivariate logistic regression analyses were applied. RESULTS: A highly statistically significant association (P = 0.001) was demonstrated between hepatocellular carcinoma and HBsAg positivity and the presence of hepatitis C virus antibodies. Diabetes mellitus was significantly (P = 0.018) associated with an increased risk of hepatocellular carcinoma. A statistically significant inverse association was shown between low parity and the risk of hepatocellular carcinoma (P = 0.033). The risk increased significantly with a longer history of cigarette smoking (P = 0.044), as well as the daily consumption of hard liquor (P = 0.049). A weekly intake of fish (P = 0.003) and yogurt (P = 0.003) and daily intake of boiled vegetables (P = 0.001) were reported more frequently by controls than hepatocellular carcinoma cases. In the current study, a high intake of salty food also significantly increased the risk of hepatocellular carcinoma (P = 0.027). Based on multivariate analysis, the presence of hepatitis C virus antibodies (OR = 24.6, P = 0.001) and duration of smoking > or =25 years (OR = 3.8, P = 0.020) were significantly related to hepatocellular carcinoma, whereas the daily consumption of boiled vegetables (OR = 0.1, P = 0.011) was inversely associated with the risk of hepatocellular carcinoma. CONCLUSIONS: The findings obtained in the current study support the hypotheses that non-viral factors, such as lifestyle factors, reproductive factors, and a history of diabetes, might be involved in the etiology of hepatocellular carcinoma.
Authors: Jake E Thistle; Jessica L Petrick; Baiyu Yang; Marie C Bradley; Barry I Graubard; Katherine A McGlynn Journal: Cancer Epidemiol Date: 2018-07-06 Impact factor: 2.984
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Authors: C Bamia; P Lagiou; M Jenab; K Aleksandrova; V Fedirko; D Trichopoulos; K Overvad; A Tjønneland; A Olsen; F Clavel-Chapelon; M-C Boutron-Ruault; M Kvaskoff; V A Katzke; T Kühn; H Boeing; U Nöthlings; D Palli; S Sieri; S Panico; R Tumino; A Naccarati; H B Bueno-de-Mesquita; P H M Peeters; E Weiderpass; G Skeie; J R Quirós; A Agudo; M-D Chirlaque; M-J Sanchez; E Ardanaz; M Dorronsoro; U Ericson; L M Nilsson; M Wennberg; K-T Khaw; N Wareham; T J Key; R C Travis; P Ferrari; M Stepien; T Duarte-Salles; T Norat; N Murphy; E Riboli; A Trichopoulou Journal: Br J Cancer Date: 2015-03-31 Impact factor: 7.640
Authors: Christina Bamia; Pagona Lagiou; Mazda Jenab; Antonia Trichopoulou; Veronika Fedirko; Krasimira Aleksandrova; Tobias Pischon; Kim Overvad; Anja Olsen; Anne Tjønneland; Marie-Christine Boutron-Ruault; Guy Fagherazzi; Antoine Racine; Tilman Kuhn; Heiner Boeing; Anna Floegel; Vasiliki Benetou; Domenico Palli; Sara Grioni; Salvatore Panico; Rosario Tumino; Paolo Vineis; H B Bueno-de-Mesquita; Vincent K Dik; Nirmala Bhoo-Pathy; Cuno S P M Uiterwaal; Elisabete Weiderpass; Eiliv Lund; J Ramón Quirós; Raul Zamora-Ros; Esther Molina-Montes; Maria-Dolores Chirlaque; Eva Ardanaz; Miren Dorronsoro; Björn Lindkvist; Peter Wallström; Lena Maria Nilsson; Malin Sund; Kay-Tee Khaw; Nick Wareham; Kathryn E Bradbury; Ruth C Travis; Pietro Ferrari; Talita Duarte-Salles; Magdalena Stepien; Marc Gunter; Neil Murphy; Elio Riboli; Dimitrios Trichopoulos Journal: Int J Cancer Date: 2014-09-24 Impact factor: 7.396
Authors: V Fedirko; A Trichopolou; C Bamia; T Duarte-Salles; E Trepo; K Aleksandrova; U Nöthlings; A Lukanova; P Lagiou; P Boffetta; D Trichopoulos; V A Katzke; K Overvad; A Tjønneland; L Hansen; M C Boutron-Ruault; G Fagherazzi; N Bastide; S Panico; S Grioni; P Vineis; D Palli; R Tumino; H B Bueno-de-Mesquita; P H Peeters; G Skeie; D Engeset; C L Parr; P Jakszyn; M J Sánchez; A Barricarte; P Amiano; M Chirlaque; J R Quirós; M Sund; M Werner; E Sonestedt; U Ericson; T J Key; K T Khaw; P Ferrari; I Romieu; E Riboli; M Jenab Journal: Ann Oncol Date: 2013-05-12 Impact factor: 32.976