| Literature DB >> 21387092 |
Bin-Tao Huang1, Yu Wang1, Qing-Feng Du1, Jun Yang1, Jessica Yu2, Qing-Chun Zeng3, Na Xu1, Jin-Fang Zhang1, Lu-Lu Xu1, Xu-Jing Luo1, Yong-Qiang Wei1, Xiao-Li Liu4.
Abstract
High-dose arabinoside (HiDAC) and daunorubicin (DNR)-based chemotherapy are the primary consolidation treatment options for older adults (50-60 years old) with acute myeloid leukemia in China. We analyzed the event-free survival (EFS) and hospital treatment charges of older adult patients with different cytogenetic risk profiles. In patients with a better/intermediate risk profile, the average total treatment cost of HiDAC was similar to that of DNR (P = 0.11). A 5-year follow-up of patients with better/intermediate cytogenetic risk profiles revealed that the median EFS of patients who received HiDAC was significantly longer than for patients who received the DNR-based regimen (27 vs. 20 months, P = 0.03). Average cost per year of life saved was 18,746.84 USD for HiDAC, compared to 32,733.37 USD for DNR. In contrast, for patients with a poor cytogenetic risk profile, the average total treatment cost for HiDAC was higher than for DNR (P < 0.005). In addition, the median EFS in the HiDAC protocol group was significantly lower than in the DNR group (11 vs. 20 months, P = 0.003). Meanwhile, in this risk group, the average cost per year of life saved was 103,237.70 USD compared to 32,277.93 USD, respectively, in the HiDAC and DNR regimens. We conclude that HiDAC is a more efficacious and cost-effective consolidation treatment regimen in the better/intermediate risk group, while the DNR-based regimen is more cost-effective in the poor risk group.Entities:
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Year: 2011 PMID： 21387092 DOI： 10.1007/s12185-011-0804-0
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490