PURPOSE OF REVIEW: This review considers the recent literature pertaining to the neurobiology, genetics and treatment of Tourette syndrome. RECENT FINDINGS: Over the last several years, both neuropathological and genetic findings have further focused attention on long-standing hypotheses regarding the role of the basal ganglia in causing tics and Tourette syndrome. Moreover, although the field awaits the results the first large-scale genetic studies, recent findings have already mirrored developments in the neuropsychiatric genetics literature more broadly, highlighting the value of the study of rare variation and the overlap of risks among seemingly disparate diagnostic categories. Finally, treatment studies have underscored the importance of cognitive-behavioral as well as pharmacological interventions for the treatment of tic disorders. SUMMARY: Recent findings have led to novel, testable hypotheses regarding the molecular and cellular mechanisms underlying Tourette syndrome. These, in turn, have begun to provide new avenues to conceptualizing treatment strategies. Although the development of additional medication options is a pressing need, recent data has demonstrated both the safety and efficacy of nonpharmacological approaches.
PURPOSE OF REVIEW: This review considers the recent literature pertaining to the neurobiology, genetics and treatment of Tourette syndrome. RECENT FINDINGS: Over the last several years, both neuropathological and genetic findings have further focused attention on long-standing hypotheses regarding the role of the basal ganglia in causing tics and Tourette syndrome. Moreover, although the field awaits the results the first large-scale genetic studies, recent findings have already mirrored developments in the neuropsychiatric genetics literature more broadly, highlighting the value of the study of rare variation and the overlap of risks among seemingly disparate diagnostic categories. Finally, treatment studies have underscored the importance of cognitive-behavioral as well as pharmacological interventions for the treatment of tic disorders. SUMMARY: Recent findings have led to novel, testable hypotheses regarding the molecular and cellular mechanisms underlying Tourette syndrome. These, in turn, have begun to provide new avenues to conceptualizing treatment strategies. Although the development of additional medication options is a pressing need, recent data has demonstrated both the safety and efficacy of nonpharmacological approaches.
Authors: Stéphane Jamain; Hélène Quach; Catalina Betancur; Maria Råstam; Catherine Colineaux; I Carina Gillberg; Henrik Soderstrom; Bruno Giros; Marion Leboyer; Christopher Gillberg; Thomas Bourgeron Journal: Nat Genet Date: 2003-05 Impact factor: 38.330
Authors: Annemieke J M H Verkerk; Carol A Mathews; Marijke Joosse; Bert H J Eussen; Peter Heutink; Ben A Oostra Journal: Genomics Date: 2003-07 Impact factor: 5.736
Authors: Andrés Martin; Lawrence Scahill; George M Anderson; Michael Aman; L Eugene Arnold; James McCracken; Christopher J McDougle; Elaine Tierney; Shirley Chuang; Benedetto Vitiello Journal: Am J Psychiatry Date: 2004-06 Impact factor: 18.112
Authors: Bradley S Peterson; Prakash Thomas; Michael J Kane; Lawrence Scahill; Heping Zhang; Richard Bronen; Robert A King; James F Leckman; Lawrence Staib Journal: Arch Gen Psychiatry Date: 2003-04
Authors: Kyle A Williams; Jean-Dominique Gallezot; Vladimir Pogorelov; Lissandra Castellan Baldan; Maximiliano Rapanelli; Michael Crowley; George M Anderson; Erin Loring; Roxanne Gorczyca; Eileen Billingslea; Suzanne Wasylink; Kaitlyn E Panza; A Gulhan Ercan-Sencicek; Kuakarun Krusong; Bennett L Leventhal; Hiroshi Ohtsu; Michael H Bloch; Zoë A Hughes; John H Krystal; Linda Mayes; Ivan de Araujo; Yu-Shin Ding; Matthew W State; Christopher Pittenger Journal: Neuron Date: 2014-01-08 Impact factor: 17.173
Authors: Peristera Paschou; Thomas V Fernandez; Frank Sharp; Gary A Heiman; Pieter J Hoekstra Journal: Int Rev Neurobiol Date: 2013 Impact factor: 3.230