Literature DB >> 21384160

In vitro evidence for the protective role of Sida rhomboidea. Roxb extract against LDL oxidation and oxidized LDL-induced apoptosis in human monocyte-derived macrophages.

Menaka C Thounaojam1, Ravirajsinh N Jadeja, Ranjisinh V Devkar, A V Ramachandran.   

Abstract

The present study was undertaken to evaluate protective role of S. rhomboidea. Roxb (SR) leaf extract against in vitro low-density lipoprotein (LDL) oxidation and oxidized LDL (Ox-LDL) induced macrophage apoptosis. Copper and cell-mediated LDL oxidation, Ox-LDL-induced peroxyl radical generation, mitochondrial activity, and apoptosis in human monocyte-derived macrophages (HMDMs) were assessed in presence of SR extract. Results clearly indicated that SR was capable of reducing LDL oxidation and formation of intermediary oxidation products. Also, SR successfully attenuated peroxyl radical formation, mitochondrial dysfunction, nuclear condensation, and apoptosis in Ox-LDL-exposed HMDMs. This scientific report is the first detailed investigation that establishes anti-atherosclerotic potential of SR extract.

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Year:  2011        PMID： 21384160     DOI： 10.1007/s12012-011-9110-6

Source DB:  PubMed          Journal:  Cardiovasc Toxicol        ISSN： 1530-7905            Impact factor:   3.231


  5 in total

1.  Flavonoid rich extract of Murraya Koenigii alleviates in-vitro LDL oxidation and oxidized LDL induced apoptosis in raw 264.7 Murine macrophage cells.

Authors:  Tejal K Gajaria; Dipak K Patel; Ranjitsinh V Devkar; A V Ramachandran
Journal:  J Food Sci Technol       Date:  2014-05-10       Impact factor: 2.701

2.  Effect of essential oil of traditional two Saudi mint types and its possible role in cardiovascular and throat health.

Authors:  Ahmed M Ahmed; Hani A Ozbak; Hassan A Hemeg
Journal:  Int J Clin Exp Med       Date:  2015-05-15

3.  Protective effect of Nelumbo nucifera (Gaertn.) against H2O2-induced oxidative stress on H9c2 cardiomyocytes.

Authors:  Rajendran Harishkumar; Murugesan Susitra Manjari; Chellan Rose; Chinnadurai Immanuel Selvaraj
Journal:  Mol Biol Rep       Date:  2019-12-11       Impact factor: 2.316

4.  Sida rhomboidea. Roxb leaf extract down-regulates expression of PPARγ2 and leptin genes in high fat diet fed C57BL/6J Mice and retards in vitro 3T3L1 pre-adipocyte differentiation.

Authors:  Menaka C Thounaojam; Ravirajsinh N Jadeja; Umed V Ramani; Ranjitsinh V Devkar; A V Ramachandran
Journal:  Int J Mol Sci       Date:  2011-07-19       Impact factor: 5.923

5.  Coriandrum sativum L. seed extract mitigates lipotoxicity in RAW 264.7 cells and prevents atherogenic changes in rats.

Authors:  Dipak Patel; Swati Desai; Tejal Gajaria; Ranjitsinh Devkar; A V Ramachandran
Journal:  EXCLI J       Date:  2013-04-10       Impact factor: 4.068
  5 in total

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