Literature DB >> 21383691

Transcriptional regulation of cellular senescence.

F Lanigan1, J G Geraghty, A P Bracken.   

Abstract

Cellular senescence is an irreversible arrest of proliferation. It is activated when a cell encounters stress such as DNA damage, telomere shortening or oncogene activation. Like apoptosis, it impedes tumour progression and acts as a barrier that pre-neoplastic cells must overcome during their evolution toward the full tumourigenic state. This review focuses on the role of transcriptional regulators in the control of cellular senescence, explores how their function is perturbed in cancer and discusses the potential to harness this knowledge for future cancer therapies.

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Year:  2011        PMID： 21383691     DOI： 10.1038/onc.2011.34

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  48 in total

1.  Downregulation of splicing factor SRSF3 induces p53β, an alternatively spliced isoform of p53 that promotes cellular senescence.

Authors:  Y Tang; I Horikawa; M Ajiro; A I Robles; K Fujita; A M Mondal; J K Stauffer; Z-M Zheng; C C Harris
Journal:  Oncogene       Date:  2012-07-09       Impact factor: 9.867

2.  Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid.

Authors:  Damián E Berardi; Carolina Flumian; Paola B Campodónico; Alejandro J Urtreger; María I Diaz Bessone; Andrea N Motter; Elisa D Bal de Kier Joffé; Eduardo F Farias; Laura B Todaro
Journal:  Cell Oncol (Dordr)       Date:  2015-06-05       Impact factor: 6.730

3.  Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells.

Authors:  Jason P Carey; Ashley Evans Knowell; Swathi Chinaranagari; Jaideep Chaudhary
Journal:  Anticancer Res       Date:  2013-10       Impact factor: 2.480

4.  Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

Authors:  Gundula Streubel; Darren J Fitzpatrick; Giorgio Oliviero; Andrea Scelfo; Bruce Moran; Sudipto Das; Nayla Munawar; Ariane Watson; Kieran Wynne; Gian Luca Negri; Eugene T Dillon; SriGanesh Jammula; Karsten Hokamp; Darran P O'Connor; Diego Pasini; Gerard Cagney; Adrian P Bracken
Journal:  EMBO J       Date:  2017-05-29       Impact factor: 11.598

5.  A positive feedback loop between Pim-1 kinase and HBP1 transcription factor contributes to hydrogen peroxide-induced premature senescence and apoptosis.

Authors:  Shuya Wang; Zhengyi Cao; Junhui Xue; Hui Li; Wei Jiang; Yuning Cheng; Gang Li; Xiaowei Zhang
Journal:  J Biol Chem       Date:  2017-03-27       Impact factor: 5.157

Review 6.  Killing the second messenger: targeting loss of cell cycle control in endocrine-resistant breast cancer.

Authors:  Carol A Lange; Douglas Yee
Journal:  Endocr Relat Cancer       Date:  2011-07-04       Impact factor: 5.678

Review 7.  What makes oncogenes mutually exclusive?

Authors:  Jaroslaw Cisowski; Martin O Bergo
Journal:  Small GTPases       Date:  2016-07-14

8.  Pak2 kinase promotes cellular senescence and organismal aging.

Authors:  Jong-Sun Lee; Yan Mo; Haiyun Gan; Rebecca J Burgess; Darren J Baker; Jan M van Deursen; Zhiguo Zhang
Journal:  Proc Natl Acad Sci U S A       Date:  2019-06-17       Impact factor: 11.205

9.  Geriatric muscle stem cells switch reversible quiescence into senescence.

Authors:  Pedro Sousa-Victor; Susana Gutarra; Laura García-Prat; Javier Rodriguez-Ubreva; Laura Ortet; Vanessa Ruiz-Bonilla; Mercè Jardí; Esteban Ballestar; Susana González; Antonio L Serrano; Eusebio Perdiguero; Pura Muñoz-Cánoves
Journal:  Nature       Date:  2014-02-12       Impact factor: 49.962

10.  Geroconversion of aged muscle stem cells under regenerative pressure.

Authors:  Pedro Sousa-Victor; Eusebio Perdiguero; Pura Muñoz-Cánoves
Journal:  Cell Cycle       Date:  2014       Impact factor: 4.534
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