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Literature DB >> 21383627

Mitochondrial protection by resveratrol.

Zoltan Ungvari¹, William E Sonntag, Rafael de Cabo, Joseph A Baur, Anna Csiszar.

Abstract

Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2011 PMID： 21383627 PMCID： PMC3123408 DOI： 10.1097/JES.0b013e3182141f80

Source DB: PubMed Journal: Exerc Sport Sci Rev ISSN： 0091-6331 Impact factor: 6.230

35 in total

1. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

Authors: Marie Lagouge; Carmen Argmann; Zachary Gerhart-Hines; Hamid Meziane; Carles Lerin; Frederic Daussin; Nadia Messadeq; Jill Milne; Philip Lambert; Peter Elliott; Bernard Geny; Markku Laakso; Pere Puigserver; Johan Auwerx
Journal: Cell Date: 2006-11-16 Impact factor: 41.582

2. Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency.

Authors: G López-Lluch; N Hunt; B Jones; M Zhu; H Jamieson; S Hilmer; M V Cascajo; J Allard; D K Ingram; P Navas; R de Cabo
Journal: Proc Natl Acad Sci U S A Date: 2006-01-30 Impact factor: 11.205

3. Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice.

Authors: Mengwei Zang; Shanqin Xu; Karlene A Maitland-Toolan; Adriana Zuccollo; Xiuyun Hou; Bingbing Jiang; Michel Wierzbicki; Tony J Verbeuren; Richard A Cohen
Journal: Diabetes Date: 2006-08 Impact factor: 9.461

Review 4. Therapeutic potential of resveratrol: the in vivo evidence.

Authors: Joseph A Baur; David A Sinclair
Journal: Nat Rev Drug Discov Date: 2006-05-26 Impact factor: 84.694

Review 5. Dietary interventions to extend life span and health span based on calorie restriction.

Authors: Robin K Minor; Joanne S Allard; Caitlin M Younts; Theresa M Ward; Rafael de Cabo
Journal: J Gerontol A Biol Sci Med Sci Date: 2010-04-06 Impact factor: 6.053

6. Resveratrol stimulates AMP kinase activity in neurons.

Authors: Biplab Dasgupta; Jeffrey Milbrandt
Journal: Proc Natl Acad Sci U S A Date: 2007-04-16 Impact factor: 11.205

7. Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

Authors: Enzo Nisoli; Cristina Tonello; Annalisa Cardile; Valeria Cozzi; Renata Bracale; Laura Tedesco; Sestina Falcone; Alessandra Valerio; Orazio Cantoni; Emilio Clementi; Salvador Moncada; Michele O Carruba
Journal: Science Date: 2005-10-14 Impact factor: 47.728

8. Resveratrol improves health and survival of mice on a high-calorie diet.

Authors: Joseph A Baur; Kevin J Pearson; Nathan L Price; Hamish A Jamieson; Carles Lerin; Avash Kalra; Vinayakumar V Prabhu; Joanne S Allard; Guillermo Lopez-Lluch; Kaitlyn Lewis; Paul J Pistell; Suresh Poosala; Kevin G Becker; Olivier Boss; Dana Gwinn; Mingyi Wang; Sharan Ramaswamy; Kenneth W Fishbein; Richard G Spencer; Edward G Lakatta; David Le Couteur; Reuben J Shaw; Placido Navas; Pere Puigserver; Donald K Ingram; Rafael de Cabo; David A Sinclair
Journal: Nature Date: 2006-11-01 Impact factor: 49.962

9. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal: Nature Date: 2003-08-24 Impact factor: 49.962

10. Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Authors: Jason G Wood; Blanka Rogina; Siva Lavu; Konrad Howitz; Stephen L Helfand; Marc Tatar; David Sinclair
Journal: Nature Date: 2004-07-14 Impact factor: 69.504

39 in total

Review 1. New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates--Nrf2 activators and GSK-3 inhibitors.

Authors: Michael Maes; Zdenĕk Fišar; Miguel Medina; Giovanni Scapagnini; Gabriel Nowak; Michael Berk
Journal: Inflammopharmacology Date: 2012-01-24 Impact factor: 4.473

2. Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells.

Authors: Valérie Desquiret-Dumas; Naïg Gueguen; Géraldine Leman; Stéphanie Baron; Valérie Nivet-Antoine; Stéphanie Chupin; Arnaud Chevrollier; Emilie Vessières; Audrey Ayer; Marc Ferré; Dominique Bonneau; Daniel Henrion; Pascal Reynier; Vincent Procaccio
Journal: J Biol Chem Date: 2013-10-31 Impact factor: 5.157

3. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment.

Authors: Anna Csiszar; Danuta Sosnowska; Mingyi Wang; Edward G Lakatta; William E Sonntag; Zoltan Ungvari
Journal: J Gerontol A Biol Sci Med Sci Date: 2012-01-04 Impact factor: 6.053

Review 4. Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies.

Authors: Hideki Igarashi; Toshifumi Takahashi; Satoru Nagase
Journal: Reprod Med Biol Date: 2015-05-09

5. Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock.

Authors: Hao Wang; Yuxia Guan; Mehmet Akif Karamercan; Lan Ye; Tricia Bhatti; Lance B Becker; Joseph A Baur; Carrie A Sims
Journal: Shock Date: 2015-08 Impact factor: 3.454

6. Resveratrol supplementation at old age reverts changes associated with aging in inflammatory, oxidative and apoptotic markers in rat heart.

Authors: Rubén Torregrosa-Muñumer; Elena Vara; Jesús Ángel Fernández-Tresguerres; Ricardo Gredilla
Journal: Eur J Nutr Date: 2021-01-02 Impact factor: 5.614

Review 10. Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence.

Authors: Anatoly Samoylenko; Jubayer Al Hossain; Daniela Mennerich; Sakari Kellokumpu; Jukka Kalervo Hiltunen; Thomas Kietzmann
Journal: Antioxid Redox Signal Date: 2013-04-15 Impact factor: 8.401