Literature DB >> 21382895

Targeting dimethylarginine dimethylaminohydrolases in pulmonary arterial hypertension: a new approach to improve vascular dysfunction?

Jay L Zweier, M A Hassan Talukder.   

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Year:  2011        PMID： 21382895      PMCID： PMC3221456          DOI： 10.1161/CIRCULATIONAHA.110.017038

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


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  19 in total

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3.  Phosphodiesterase inhibition improves agonist-induced relaxation of hypertensive pulmonary arteries.

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4.  Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension.

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Review 5.  The lung in the balance: arginine, methylated arginines, and nitric oxide.

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6.  Evidence for the pathophysiological role of endogenous methylarginines in regulation of endothelial NO production and vascular function.

Authors:  Arturo J Cardounel; Hongmei Cui; Alexandre Samouilov; Wesley Johnson; Patrick Kearns; Ah-Lim Tsai; Vladomir Berka; Jay L Zweier
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7.  Endogenous methylarginines modulate superoxide as well as nitric oxide generation from neuronal nitric-oxide synthase: differences in the effects of monomethyl- and dimethylarginines in the presence and absence of tetrahydrobiopterin.

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8.  Regulation of eNOS-derived superoxide by endogenous methylarginines.

Authors:  Lawrence J Druhan; Scott P Forbes; Arthur J Pope; Chun-An Chen; Jay L Zweier; Arturo J Cardounel
Journal:  Biochemistry       Date:  2008-06-14       Impact factor: 3.162

Review 9.  Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems.

Authors:  Fredrik Palm; Maristela L Onozato; Zaiming Luo; Christopher S Wilcox
Journal:  Am J Physiol Heart Circ Physiol       Date:  2007-10-12       Impact factor: 4.733

Review 10.  Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond.

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1.  Plasma L-arginine levels distinguish pulmonary arterial hypertension from left ventricular systolic dysfunction.

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