Literature DB >> 21382377

The in-situ pig heart with regional ischemia/reperfusion - ready for translation.

Gerd Heusch1, Andreas Skyschally, Rainer Schulz.   

Abstract

The pig heart in situ with regional myocardial ischemia and reperfusion is of unique translational value. Cardiac size, heart rate and blood pressure are similar to those in humans. The temporal and spatial development of myocardial infarction resembles that seen in humans. Technically, the pig heart permits precise control of coronary blood flow during ischemia and reperfusion, includes an intra-individual remote control zone for comparison, and permits the sequential sampling of microdialysates and biopsies for further biochemical, molecular and morphological analyses. Conceptually, all cardioprotective phenomena, including hibernation, ischemic preconditioning, ischemic postconditioning, and remote conditioning, have been demonstrated in pig hearts. The cardioprotective signalling is in part similar, but in part also different from that in rodent hearts.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21382377     DOI： 10.1016/j.yjmcc.2011.02.016

Source DB:  PubMed          Journal:  J Mol Cell Cardiol        ISSN： 0022-2828            Impact factor:   5.000


  37 in total

1.  Transgenic swine: expression of human CD39 protects against myocardial injury.

Authors:  Debra G Wheeler; Matthew E Joseph; Shouvik D Mahamud; William L Aurand; Peter J Mohler; Vincent J Pompili; Karen M Dwyer; Mark B Nottle; Sharon J Harrison; Anthony J F d'Apice; Simon C Robson; Peter J Cowan; Richard J Gumina
Journal:  J Mol Cell Cardiol       Date:  2012-01-12       Impact factor: 5.000

2.  In vitro Models of Ischemia-Reperfusion Injury.

Authors:  Timothy Chen; Gordana Vunjak-Novakovic
Journal:  Regen Eng Transl Med       Date:  2018-05-10

3.  Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway.

Authors:  Sofia-Iris Bibli; Ioanna Andreadou; Athanasia Chatzianastasiou; Christos Tzimas; Despina Sanoudou; Evangelia Kranias; Peter Brouckaert; Ciro Coletta; Csaba Szabo; Dimitrios Th Kremastinos; Efstathios K Iliodromitis; Andreas Papapetropoulos
Journal:  Cardiovasc Res       Date:  2015-04-13       Impact factor: 10.787

4.  Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction.

Authors:  Romain Gallet; James Dawkins; Jackelyn Valle; Eli Simsolo; Geoffrey de Couto; Ryan Middleton; Eleni Tseliou; Daniel Luthringer; Michelle Kreke; Rachel R Smith; Linda Marbán; Bijan Ghaleh; Eduardo Marbán
Journal:  Eur Heart J       Date:  2017-01-14       Impact factor: 29.983

5.  Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology.

Authors:  Stephanie Thorn; Albert J Sinusas
Journal:  J Nucl Cardiol       Date:  2015-02-20       Impact factor: 5.952

Review 6.  Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.

Authors:  Hans Erik Bøtker; Derek Hausenloy; Ioanna Andreadou; Salvatore Antonucci; Kerstin Boengler; Sean M Davidson; Soni Deshwal; Yvan Devaux; Fabio Di Lisa; Moises Di Sante; Panagiotis Efentakis; Saveria Femminò; David García-Dorado; Zoltán Giricz; Borja Ibanez; Efstathios Iliodromitis; Nina Kaludercic; Petra Kleinbongard; Markus Neuhäuser; Michel Ovize; Pasquale Pagliaro; Michael Rahbek-Schmidt; Marisol Ruiz-Meana; Klaus-Dieter Schlüter; Rainer Schulz; Andreas Skyschally; Catherine Wilder; Derek M Yellon; Peter Ferdinandy; Gerd Heusch
Journal:  Basic Res Cardiol       Date:  2018-08-17       Impact factor: 17.165

7.  Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures.

Authors:  Mai M Abdelhafez; Jane Shaw; Jonas Wilbs; Alain Despont; Robert Rieben
Journal:  J Vis Exp       Date:  2018-03-12       Impact factor: 1.355

8.  microRNA expression and its potential role in cardioprotection by ischemic postconditioning in pigs.

Authors:  Theodor Baars; Andreas Skyschally; Ludger Klein-Hitpass; Elke Cario; Raimund Erbel; Gerd Heusch; Petra Kleinbongard
Journal:  Pflugers Arch       Date:  2014-01-05       Impact factor: 3.657

9.  TNF-α blockade improves early post-resuscitation survival and hemodynamics in a swine model of ischemic ventricular fibrillation.

Authors:  James T Niemann; Scott T Youngquist; Atman P Shah; Joseph L Thomas; John P Rosborough
Journal:  Resuscitation       Date:  2012-06-07       Impact factor: 5.262

10.  The antiarrhythmic dipeptide ZP1609 (danegaptide) when given at reperfusion reduces myocardial infarct size in pigs.

Authors:  Andreas Skyschally; Barbara Walter; Rie Schultz Hansen; Gerd Heusch
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2013-02-09       Impact factor: 3.000
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