Literature DB >> 21381769

Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery.

Eric Marsault1, Mark L Peterson.   

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Year:  2011        PMID： 21381769     DOI： 10.1021/jm1012374

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


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  117 in total

1.  β-Strand mimics based on tetrahydropyridazinedione (tpd) peptide stitching.

Authors:  Chang Won Kang; Matthew P Sarnowski; Sujeewa Ranatunga; Lukasz Wojtas; Rainer S Metcalf; Wayne C Guida; Juan R Del Valle
Journal:  Chem Commun (Camb)       Date:  2015-11-21       Impact factor: 6.222

2.  A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.

Authors:  Henning S G Beckmann; Feilin Nie; Caroline E Hagerman; Henrik Johansson; Yaw Sing Tan; David Wilcke; David R Spring
Journal:  Nat Chem       Date:  2013-08-25       Impact factor: 24.427

3.  Ribosomal Synthesis of Macrocyclic Peptides in Vitro and in Vivo Mediated by Genetically Encoded Aminothiol Unnatural Amino Acids.

Authors:  John R Frost; Nicholas T Jacob; Louis J Papa; Andrew E Owens; Rudi Fasan
Journal:  ACS Chem Biol       Date:  2015-05-15       Impact factor: 5.100

4.  Modular Synthesis of Novel Macrocycles Bearing α,β-Unsaturated Chemotypes through a Series of One-Pot, Sequential Protocols.

Authors:  Salim Javed; Mahipal Bodugam; Jessica Torres; Arghya Ganguly; Paul R Hanson
Journal:  Chemistry       Date:  2016-04-05       Impact factor: 5.236

5.  Ribosomal Synthesis of Natural-Product-Like Bicyclic Peptides in Escherichia coli.

Authors:  Nina Bionda; Rudi Fasan
Journal:  Chembiochem       Date:  2015-08-06       Impact factor: 3.164

6.  Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer.

Authors:  Yong Zhang; Benjamin A Seigal; Nicholas K Terrett; Randy L Talbott; Joseph Fargnoli; Joseph G Naglich; Charu Chaudhry; Shana L Posy; Ragini Vuppugalla; Georgia Cornelius; Ming Lei; Chunlei Wang; Yingru Zhang; Robert J Schmidt; Donna D Wei; Michael M Miller; Martin P Allen; Ling Li; Percy H Carter; Gregory D Vite; Robert M Borzilleri
Journal:  ACS Med Chem Lett       Date:  2015-05-27       Impact factor: 4.345

7.  Macrocyclic MEK1/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A/C gene mutation.

Authors:  Wei Wu; Mahendra D Chordia; Barry P Hart; E Sathyajith Kumarasinghe; Min K Ji; Ajay Bhargava; Michael W Lawlor; Ji-Yeon Shin; Fusako Sera; Shunichi Homma; Antoine Muchir; Uday R Khire; Howard J Worman
Journal:  Bioorg Med Chem       Date:  2016-12-09       Impact factor: 3.641

Review 8.  Recent advances in the discovery and development of factor XI/XIa inhibitors.

Authors:  Rami A Al-Horani; Daniel K Afosah
Journal:  Med Res Rev       Date:  2018-05-04       Impact factor: 12.944

9.  Template-constrained macrocyclic peptides prepared from native, unprotected precursors.

Authors:  Kenneth V Lawson; Tristan E Rose; Patrick G Harran
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205

10.  In Search of the Optimal Macrocyclization Site for Neurotensin.

Authors:  Marc Sousbie; Élie Besserer-Offroy; Rebecca L Brouillette; Jean-Michel Longpré; Richard Leduc; Philippe Sarret; Éric Marsault
Journal:  ACS Med Chem Lett       Date:  2018-01-29       Impact factor: 4.345
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