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Literature DB >> 2138125

Phenotypic changes in a CD4+ lymphocyte subset correlate with a conversion from suppressor to helper inducer function.

Abstract

The monoclonal antibodies WR16 (CD45RA) and WR19 were used to isolate two reciprocal subsets of CD4 lymphocytes by negative selection. The CD4+/WR16-/WR19+ subset exhibited helper-inducer activity in a pokeweed mitogen (PWM)-driven Ig secretion assay, whereas the CD4+/WR16+/WR19- subset showed suppressor activity. When the CD4+/WR16+/WR19- subset was cultured in phytohaemagglutinin (PHA) or purified protein derivative (PPD) there was increased expression of the antigen binding WR19 but the cells remained WR16 negative. Cultures of CD4+/WR16+/WR19- lymphocytes with PHA or PPD induced a phenotypic change that resulted in a population which was CD4+/WR16-/WR19+. Investigation of the functional activity of the CD4+/WR16+/WR19- subset, before and after activation and phenotypic change to WR16-/WR19+, indicated that the change in phenotype correlated with a functional conversion from suppressor to helper-inducer activity. These results suggest that the CD4+/WR16+/WR19- suppressor subset comprises cells that differentiate to WR16-/WR19+ helper-inducer cells after exposure to antigen or mitogen.

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Year: 1990 PMID： 2138125 PMCID： PMC1385721

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

15 in total

1. Subpopulations of T lymphocytes.

Authors: D W Mason
Journal: Immunol Lett Date: 1987-04 Impact factor: 3.685

2. Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

Authors: H M Serra; J F Krowka; J A Ledbetter; L M Pilarski
Journal: J Immunol Date: 1988-03-01 Impact factor: 5.422

3. Induction of CD4 suppressor T cells with anti-Leu-8 antibody.

Authors: M E Kanof; W Strober; S P James
Journal: J Immunol Date: 1987-07-01 Impact factor: 5.422

4. Functional heterogeneity of CD4+ T lymphocytes: two subpopulations with counteracting immunoregulatory functions identified with the monoclonal antibodies WR16 and WR19.

Authors: K Moore; A M Nesbitt
Journal: Immunology Date: 1987-06 Impact factor: 7.397

5. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells.

Authors: A N Akbar; L Terry; A Timms; P C Beverley; G Janossy
Journal: J Immunol Date: 1988-04-01 Impact factor: 5.422

6. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

Authors: T R Mosmann; H Cherwinski; M W Bond; M A Giedlin; R L Coffman
Journal: J Immunol Date: 1986-04-01 Impact factor: 5.422

10. T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation.

Authors: R P Arthur; D Mason
Journal: J Exp Med Date: 1986-04-01 Impact factor: 14.307

1 in total

1. An investigation of T-cell subset phenotype and function in the rheumatoid synovium using in situ hybridization for IL-2 mRNA.

Authors: C J Warren; W M Howell; M Bhambhani; M I Cawley; J L Smith
Journal: Immunology Date: 1991-02 Impact factor: 7.397