Literature DB >> 2138087

Different effects of 8-OH-DPAT, a 5-HT1A receptor agonist, on cortical acetylcholine release, electrocortigram and body temperature in guinea pigs and rats.

A Siniscalchi1, L Beani, C Bianchi.   

Abstract

8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) dose dependently increased cortical acetylcholine (ACh) release and the body temperature of freely moving guinea pigs. Moreover, it evoked an electroencephalographic (EEG) arousal reaction in phenobarbital-pretreated animals. 8-OH-DPAT was about 10 times less effective in increasing cortical ACh release in the rat than in the guinea pig, and did not modify the phenobarbital-synchronized EEG but dose dependently decreased body temperature. The possibility that 5-HT1A receptors play different roles, depending on the animal species, is discussed.

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Year:  1990        PMID： 2138087     DOI： 10.1016/0014-2999(90)90235-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  7 in total

1.  Evidence for an in vivo and in vitro modulation of endogenous cortical GABA release by alpha-glycerylphosphorylcholine.

Authors:  L Ferraro; S Tanganelli; L Marani; C Bianchi; L Beani; A Siniscalchi
Journal:  Neurochem Res       Date:  1996-05       Impact factor: 3.996

2.  Intra-prefrontal 8-OH-DPAT and M100907 improve visuospatial attention and decrease impulsivity on the five-choice serial reaction time task in rats.

Authors:  Catharine A Winstanley; Yogita Chudasama; Jeffrey W Dalley; David E H Theobald; Jeffrey C Glennon; Trevor W Robbins
Journal:  Psychopharmacology (Berl)       Date:  2003-04-02       Impact factor: 4.530

3.  Inhibitory effects of the psychoactive drug modafinil on gamma-aminobutyric acid outflow from the cerebral cortex of the awake freely moving guinea-pig. Possible involvement of 5-hydroxytryptamine mechanisms.

Authors:  S Tanganelli; K Fuxe; L Ferraro; A M Janson; C Bianchi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1992-04       Impact factor: 3.000

4.  5-HT1A agonists increase and 5-HT3 agonists decrease acetylcholine efflux from the cerebral cortex of freely-moving guinea-pigs.

Authors:  C Bianchi; A Siniscalchi; L Beani
Journal:  Br J Pharmacol       Date:  1990-10       Impact factor: 8.739

5.  5-HT3 receptor ligands lack modulatory influence on acetylcholine release in rat entorhinal cortex.

Authors:  R M Johnson; G T Inouye; R M Eglen; E H Wong
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-03       Impact factor: 3.000

6.  The effect of 5-HT1A receptor agonists on locomotor activity in the guinea-pig.

Authors:  J L Evenden
Journal:  Br J Pharmacol       Date:  1994-07       Impact factor: 8.739

7.  Influence of acute and chronic chlorimipramine treatment on the 5-HT receptor-mediated modulation of acetylcholine release from the cerebral cortex of freely moving guinea-pigs.

Authors:  A Siniscalchi; C Bianchi; L Beani
Journal:  Br J Pharmacol       Date:  1991-04       Impact factor: 8.739
  7 in total

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