| Literature DB >> 21378986 |
Fan Wang1, Cheng-Qi Xu, Qing He, Jian-Ping Cai, Xiu-Chun Li, Dan Wang, Xin Xiong, Yu-Hua Liao, Qiu-Tang Zeng, Yan-Zong Yang, Xiang Cheng, Cong Li, Rong Yang, Chu-Chu Wang, Gang Wu, Qiu-Lun Lu, Ying Bai, Yu-Feng Huang, Dan Yin, Qing Yang, Xiao-Jing Wang, Da-Peng Dai, Rong-Feng Zhang, Jing Wan, Jiang-Hua Ren, Si-Si Li, Yuan-Yuan Zhao, Fen-Fen Fu, Yuan Huang, Qing-Xian Li, Sheng-Wei Shi, Nan Lin, Zhen-Wei Pan, Yue Li, Bo Yu, Yan-Xia Wu, Yu-He Ke, Jian Lei, Nan Wang, Chun-Yan Luo, Li-Ying Ji, Lian-Jun Gao, Lei Li, Hui Liu, Er-Wen Huang, Jin Cui, Na Jia, Xiang Ren, Hui Li, Tie Ke, Xian-Qin Zhang, Jing-Yu Liu, Mu-Gen Liu, Hao Xia, Bo Yang, Li-Song Shi, Yun-Long Xia, Xin Tu, Qing K Wang.
Abstract
Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10⁻³, stage 2 validation; P = 3.00 × 10⁻³, P = 1.19 × 10⁻⁸ and P = 4.00 × 10⁻³ in three independent stage 3 replication populations; P = 4.87 × 10⁻¹², odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.Entities:
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Year: 2011 PMID： 21378986 DOI： 10.1038/ng.783
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330