Literature DB >> 21377876

Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production.

Jieun Yoon1, Lan Cho, Sang Kook Lee, Jae-Sang Ryu.   

Abstract

A 28-membered 1,2,3-triazolyl salicylamide library was synthesized via a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition and evaluated for their abilities to inhibit NO production in LPS-activated RAW264.7 macrophage cells. Among 28 analogues, 29 g showed a significant inhibitory activity (IC(50) = 12.8 μM). The inhibitory effects of 29 g on LPS-mediated NO production in macrophage cells appeared to be associated with the suppression of iNOS expression.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21377876     DOI： 10.1016/j.bmcl.2011.02.034

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  1 in total

1.  Design, synthesis, antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione system.

Authors:  Emilia Bankowska; Jan Balzarini; Iwona E Głowacka; Andrzej E Wróblewski
Journal:  Monatsh Chem       Date:  2014-01-25       Impact factor: 1.451
  1 in total

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