Is there a relationship between bone and critical illness?

Critical illness is a result of a series of severe diseases of complicated causes. Although accumulating therapeutic strategies have been carried out for the prevention and treatment of critical illness, mortality remains high. Inflammations, electrolyte disturbances, hyperglycemia, and depressed immune function are factors that may be responsible. Recent studies have suggested that the bone influences hematopoiesis, immunity, and metabolism. Published data and our own work have led us to hypothesize that the bone plays an important role in the pathogenesis and outcome of critical illness.