| Literature DB >> 21377440 |
Abstract
After its discovery in Drosophila, the Hippo signalling pathway has been shown to regulate organ size in mammals as well. Based on recent studies, this kinase cascade appears in particular crucial for liver tissue homeostasis, by regulating both cellular proliferation and apoptosis. Thereby, Hippo signalling may appear as a key pathway in liver carcinogenesis.Entities:
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Year: 2011 PMID: 21377440 DOI: 10.1016/j.clinre.2011.01.012
Source DB: PubMed Journal: Clin Res Hepatol Gastroenterol ISSN: 2210-7401 Impact factor: 2.947