Osamu Ishihara1, Akira Kuwahara, Hidekazu Saitoh. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Saitama Medical University, Saitama, Japan. osamishr@saitama-med.ac.jp
Abstract
OBJECTIVE: To evaluate the effect of frozen-thawed blastocyst transfer on ectopic pregnancy (EP) rate. DESIGN: Retrospective analysis. SETTING: Japanese registry of assisted reproductive medicine. PATIENT(S): Women who were registered during 2008. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Rates of live birth, EP, and spontaneous abortion in single blastocyst and cleavage-stage ET cycles in both fresh and frozen-thawed were determined. RESULT(S): In the frozen-thawed single blastocyst transfer cycles, 84 EPs of 10,312 clinical pregnancies (0.81%) were reported. There were 25 EPs of 1,361 clinical pregnancies (1.8%) in fresh IVF single blastocyst transfer cycles and 19 of 1,352 (1.4%) in fresh intracytoplasmic sperm injection single blastocyst transfer cycles. The rate of EPs after frozen-thawed single blastocyst transfers varied between 0.56% and 0.97% after stratification by age group. CONCLUSION(S): Frozen-thawed blastocyst transfers have reduced EP rates significantly compared with fresh blastocyst transfers.
OBJECTIVE: To evaluate the effect of frozen-thawed blastocyst transfer on ectopic pregnancy (EP) rate. DESIGN: Retrospective analysis. SETTING: Japanese registry of assisted reproductive medicine. PATIENT(S): Women who were registered during 2008. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Rates of live birth, EP, and spontaneous abortion in single blastocyst and cleavage-stage ET cycles in both fresh and frozen-thawed were determined. RESULT(S): In the frozen-thawed single blastocyst transfer cycles, 84 EPs of 10,312 clinical pregnancies (0.81%) were reported. There were 25 EPs of 1,361 clinical pregnancies (1.8%) in fresh IVF single blastocyst transfer cycles and 19 of 1,352 (1.4%) in fresh intracytoplasmic sperm injection single blastocyst transfer cycles. The rate of EPs after frozen-thawed single blastocyst transfers varied between 0.56% and 0.97% after stratification by age group. CONCLUSION(S): Frozen-thawed blastocyst transfers have reduced EP rates significantly compared with fresh blastocyst transfers.
Authors: Ali Aflatoonian; Mohammad Ali Karimzadeh Maybodi; Nastaran Aflatoonian; Nasim Tabibnejad; Mohammad Hossein Amir-Arjmand; Mehrdad Soleimani; Behrouz Aflatoonian; Abbas Aflatoonian Journal: Int J Reprod Biomed Date: 2016-03