Vijaya Majumdar1, Rita Christopher. 1. Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore-560029, India.
Abstract
BACKGROUND: Klotho, an anti-aging gene, is a functional candidate for metabolic syndrome. We conducted a cross-sectional study to evaluate the association of the genetic variants of Klotho with metabolic syndrome and surrogates of insulin resistance in Asian Indians. METHODS: We recruited 428 clinically normal subjects for the study. Genotyping was done by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: Significant and borderline associations of the KL-VS (OR=15.88 [95%CI, 2.56-98.70], p=0.003) and C1818T (OR=0.28 [95%CI, 0.07-1.07], p=0.063) variants of the Klotho gene, respectively, were observed with metabolic syndrome. The association of the KL-VS variant with metabolic syndrome could be linked to its observed influence on high blood glucose (OR=6.92 [95% CI=1.75-27.44], p=0.006), high blood pressure (OR=5.21 [95%CI=1.00-38.43], p=0.046), insulin resistance (OR=3.59, [95%CI=1.01-12.79], p=0.048) and trend towards its association with hypertriglyceridemia (OR=3.69 [95%CI=0.92-14.77], p=0.065). CONCLUSIONS: The genetic variants of Klotho might predict risk for metabolic syndrome and insulin resistance in Asian Indians. However, larger studies in other ethnic populations are warranted to determine the role of these gene variants in the etiology of metabolic syndrome.
BACKGROUND:Klotho, an anti-aging gene, is a functional candidate for metabolic syndrome. We conducted a cross-sectional study to evaluate the association of the genetic variants of Klotho with metabolic syndrome and surrogates of insulin resistance in Asian Indians. METHODS: We recruited 428 clinically normal subjects for the study. Genotyping was done by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: Significant and borderline associations of the KL-VS (OR=15.88 [95%CI, 2.56-98.70], p=0.003) and C1818T (OR=0.28 [95%CI, 0.07-1.07], p=0.063) variants of the Klotho gene, respectively, were observed with metabolic syndrome. The association of the KL-VS variant with metabolic syndrome could be linked to its observed influence on high blood glucose (OR=6.92 [95% CI=1.75-27.44], p=0.006), high blood pressure (OR=5.21 [95%CI=1.00-38.43], p=0.046), insulin resistance (OR=3.59, [95%CI=1.01-12.79], p=0.048) and trend towards its association with hypertriglyceridemia (OR=3.69 [95%CI=0.92-14.77], p=0.065). CONCLUSIONS: The genetic variants of Klotho might predict risk for metabolic syndrome and insulin resistance in Asian Indians. However, larger studies in other ethnic populations are warranted to determine the role of these gene variants in the etiology of metabolic syndrome.
Authors: Erika J Wolf; Filomene G Morrison; Danielle R Sullivan; Mark W Logue; Rachel E Guetta; Annjanette Stone; Steven A Schichman; Regina E McGlinchey; William P Milberg; Mark W Miller Journal: Brain Behav Immun Date: 2019-03-11 Impact factor: 7.217
Authors: Giovanni Corsetti; Evasio Pasini; Tiziano M Scarabelli; Claudia Romano; Pratik R Agrawal; Carol Chen-Scarabelli; Richard Knight; Louis Saravolatz; Jagat Narula; Mario Ferrari-Vivaldi; Vincenzo Flati; Deodato Assanelli; Francesco S Dioguardi Journal: J Geriatr Cardiol Date: 2016-08 Impact factor: 3.327