Literature DB >> 21376588

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity.

Mariko Kitajima1, Masumi Iwai, Ruri Kikura-Hanajiri, Yukihiro Goda, Mitsuru Iida, Hisatoshi Yabushita, Hiromitsu Takayama.   

Abstract

Three indole alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural alkaloids.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21376588     DOI： 10.1016/j.bmcl.2011.02.036

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum.

Authors:  Mahmoud Fahmi Elsebai; Viktor Rempel; Gregor Schnakenburg; Stefan Kehraus; Christa E Müller; Gabriele M König
Journal:  ACS Med Chem Lett       Date:  2011-09-17       Impact factor: 4.345

Review 2.  Indole alkaloids from marine sources as potential leads against infectious diseases.

Authors:  Paulo H B França; Daniel P Barbosa; Daniel L da Silva; Êurica A N Ribeiro; Antônio E G Santana; Bárbara V O Santos; José M Barbosa-Filho; Jullyana S S Quintans; Rosana S S Barreto; Lucindo J Quintans-Júnior; João X de Araújo-Júnior
Journal:  Biomed Res Int       Date:  2014-06-05       Impact factor: 3.411

Review 3.  Small Molecules from Nature Targeting G-Protein Coupled Cannabinoid Receptors: Potential Leads for Drug Discovery and Development.

Authors:  Charu Sharma; Bassem Sadek; Sameer N Goyal; Satyesh Sinha; Mohammad Amjad Kamal; Shreesh Ojha
Journal:  Evid Based Complement Alternat Med       Date:  2015-11-17       Impact factor: 2.629
  3 in total

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