| Literature DB >> 21376414 |
Lihuan Shi1, Nan Qin, Lijuan Hu, Linjuan Liu, Hongquan Duan, Wenyan Niu.
Abstract
Tiliroside isolated from Chinese herb Potentilla chinensis showed therapeutic activities in diabetes. We synthesized 7 tiliroside-derivatives and examined their effects on surface GLUT4myc levels in muscle cells. Derivatives 2a and 3 increased surface GLUT4myc levels, and derivative 3 has the greatest potential. AMPK may be involved in tiliroside-derivatives-regulated GLUT4myc traffic.Entities:
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Year: 2011 PMID： 21376414 DOI： 10.1016/j.diabres.2011.02.009
Source DB: PubMed Journal: Diabetes Res Clin Pract ISSN： 0168-8227 Impact factor: 5.602