OBJECTIVE: To evaluate the association between five interleukin-1 (IL-1) and -6 gene polymorphisms and risk of high grade cervical intraepithelial neoplasia (CIN 2-3). METHODS: This case-control study investigates five common IL-1 and IL-6 gene polymorphisms in 131 women with CIN 2-3 and 209 controls by pyrosequencing and polymerase chain reaction. Associations between gene polymorphisms and risk of CIN 2-3 are analysed by univariate and multivariable models. Their combined effect on the risk of CIN is evaluated by haplotype analysis. RESULTS: In a multivariable regression model IL1A -889 (odds ratio 0.3 [95% confidence interval 0.1-0.8], p=0.01) and smoking (4.0 [1.7-9.1], p=0.001) are independently associated with the risk of high grade CIN. Haplotype analysis does not reveal any high-risk combinations for the susceptibility of CIN. CONCLUSION: The single nucleotide polymorphism IL1A -889 is independently associated with risk of high grade CIN.
OBJECTIVE: To evaluate the association between five interleukin-1 (IL-1) and -6 gene polymorphisms and risk of high grade cervical intraepithelial neoplasia (CIN 2-3). METHODS: This case-control study investigates five common IL-1 and IL-6 gene polymorphisms in 131 women with CIN 2-3 and 209 controls by pyrosequencing and polymerase chain reaction. Associations between gene polymorphisms and risk of CIN 2-3 are analysed by univariate and multivariable models. Their combined effect on the risk of CIN is evaluated by haplotype analysis. RESULTS: In a multivariable regression model IL1A -889 (odds ratio 0.3 [95% confidence interval 0.1-0.8], p=0.01) and smoking (4.0 [1.7-9.1], p=0.001) are independently associated with the risk of high grade CIN. Haplotype analysis does not reveal any high-risk combinations for the susceptibility of CIN. CONCLUSION: The single nucleotide polymorphism IL1A -889 is independently associated with risk of high grade CIN.
Authors: Akash M Mehta; Merel Mooij; Ivan Branković; Sander Ouburg; Servaas A Morré; Ekaterina S Jordanova Journal: J Immunol Res Date: 2017-02-09 Impact factor: 4.818
Authors: Camilla Natter; Stephan Polterauer; Jasmin Rahhal-Schupp; Dan Cacsire Castillo-Tong; Sophie Pils; Paul Speiser; Robert Zeillinger; Georg Heinze; Christoph Grimm Journal: Dis Markers Date: 2013-07-28 Impact factor: 3.434
Authors: K Torres-Poveda; A I Burguete-García; M Bahena-Román; R Méndez-Martínez; M A Zurita-Díaz; G López-Estrada; K Delgado-Romero; O Peralta-Zaragoza; V H Bermúdez-Morales; D Cantú; A García-Carrancá; V Madrid-Marina Journal: BMC Cancer Date: 2016-05-24 Impact factor: 4.430