Mohamed Nabih El-Gharib1, Ma Morad. 1. Department of Obstetrics & Gynecology and Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt. mohgharib@hotmail.com
Abstract
OBJECTIVE: To evaluate the use of late first trimester maternal serum inhibin-A concentrations in prediction of preeclampsia. DESIGN: Prospective study. SETTING: Tanta University Hospital. METHODS: All cases (327) were subjected to complete history taking, clinical and ultrasound examination, CBC, liver function tests, estimation of 24 h urine protein and venous blood samples were taken during the late first trimester for estimation of serum level of inhibin-A. RESULTS: First trimester maternal serum inhibin-A concentrations were significantly higher in women who subsequently develop preeclampsia than the corresponding values in healthy matched control pregnant women. CONCLUSIONS: Measurement of inhibin-A during late first trimester of pregnancy can be useful in the prediction of preeclampsia.
OBJECTIVE: To evaluate the use of late first trimester maternal serum inhibin-A concentrations in prediction of preeclampsia. DESIGN: Prospective study. SETTING: Tanta University Hospital. METHODS: All cases (327) were subjected to complete history taking, clinical and ultrasound examination, CBC, liver function tests, estimation of 24 h urine protein and venous blood samples were taken during the late first trimester for estimation of serum level of inhibin-A. RESULTS: First trimester maternal serum inhibin-A concentrations were significantly higher in women who subsequently develop preeclampsia than the corresponding values in healthy matched control pregnant women. CONCLUSIONS: Measurement of inhibin-A during late first trimester of pregnancy can be useful in the prediction of preeclampsia.
Authors: C Emily Kleinrouweler; Miranda van Uitert; Perry D Moerland; Carrie Ris-Stalpers; Joris A M van der Post; Gijs B Afink Journal: PLoS One Date: 2013-07-12 Impact factor: 3.240