| Literature DB >> 21375229 |
Atsushi Minami1, Akira Migita, Daiki Inada, Kinya Hotta, Kenji Watanabe, Hiroki Oguri, Hideaki Oikawa.
Abstract
Our recent findings of the first epoxide hydrolase Lsd19, involved in lasalocid A biosynthesis, led us to investigate a long-standing controversial issue on the mechanism of enzymatic epoxide-opening cascades. The site-directed mutagenesis and domain dissection analysis to reveal the mechanism of the reaction catalyzed by Lsd19 is examined, especially in the role of acidic amino acid pair and catalytic domains.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21375229 DOI： 10.1021/ol200100e
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005