Literature DB >> 21374112

Aging of cultured human skin fibroblasts.

C B Harley1.   

Abstract

There is substantial evidence that aging is related to the finite ability of somatic cells to divide and repair damaged tissue. Since the seminal observation of Hayflick and Moor head (1) that cultured human fibroblasts have a finite replicative lifespan, a great deal of basic biological research on aging has been based on the model of cellular senescence in vitro (2).

Entities:  

Year:  1990        PMID： 21374112     DOI： 10.1385/0-89603-150-0:25

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  4 in total

1.  End resection initiates genomic instability in the absence of telomerase.

Authors:  Jennifer A Hackett; Carol W Greider
Journal:  Mol Cell Biol       Date:  2003-12       Impact factor: 4.272

Review 2.  Cellular senescence in neuroblastoma.

Authors:  Sofia Zanotti; Bieke Decaesteker; Suzanne Vanhauwaert; Bram De Wilde; Winnok H De Vos; Frank Speleman
Journal:  Br J Cancer       Date:  2022-02-23       Impact factor: 9.075

3.  Parental responsiveness moderates the association between early-life stress and reduced telomere length.

Authors:  A Asok; K Bernard; T L Roth; J B Rosen; M Dozier
Journal:  Dev Psychopathol       Date:  2013-03-26

4.  A sequence-dependent exonuclease activity from Tetrahymena thermophila.

Authors:  Hui-I Kao Tom; Carol W Greider
Journal:  BMC Biochem       Date:  2010-11-16       Impact factor: 4.059
  4 in total

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