BACKGROUND: Coronary artery calcification (CAC) predicts mortality in normotensive individuals. We hypothesized that CAC has an impact on long-term mortality in hypertensive patients. METHODS: We followed 423 participants of the INSIGHT (International Nifedipine Study Intervention as Goal for Hypertension Therapy) calcification substudy, for the incidence of mortality as a function of CAC. All patients were hypertensive (mean age 64 ± 6 years, 48% male), without coronary artery or peripheral vascular disease, aged >55 years and with at least one more major cardiovascular (CV) risk factor. All underwent a baseline computed tomography (CT) (Dual slice) to determine the calcification score and were followed for a mean period of 14 ± 0.5 years. Mortality and the cause of death were derived from the registry of the Ministry-of-Interior Affairs. RESULTS: During the follow-up, 94 patients died; 27 from CV causes, 54 from non-CV causes and 13 of undefined causes. The prevalence of calcification at baseline was 59% (195/329) among the survivors compared to 82% (77/94) in participants who died and 96.7% (26/27) among those who died of CV causes. The incidence of CV death was 14 times higher among those with than those without CAC (9.6% (26/272) vs. 0.7% (1/151); P < 0.01). After adjusting for age, gender, left ventricular hypertrophy, proteinuria, duration of hypertension, and renal function the presence of calcification predicted all cause mortality with a hazard ratio (HR) of 1.8 (95% confidence interval (CI) 1.04-3.07). CONCLUSIONS: CAC is associated with long-term mortality in asymptomatic hypertensive adults.
BACKGROUND:Coronary artery calcification (CAC) predicts mortality in normotensive individuals. We hypothesized that CAC has an impact on long-term mortality in hypertensivepatients. METHODS: We followed 423 participants of the INSIGHT (International Nifedipine Study Intervention as Goal for Hypertension Therapy) calcification substudy, for the incidence of mortality as a function of CAC. All patients were hypertensive (mean age 64 ± 6 years, 48% male), without coronary artery or peripheral vascular disease, aged >55 years and with at least one more major cardiovascular (CV) risk factor. All underwent a baseline computed tomography (CT) (Dual slice) to determine the calcification score and were followed for a mean period of 14 ± 0.5 years. Mortality and the cause of death were derived from the registry of the Ministry-of-Interior Affairs. RESULTS: During the follow-up, 94 patients died; 27 from CV causes, 54 from non-CV causes and 13 of undefined causes. The prevalence of calcification at baseline was 59% (195/329) among the survivors compared to 82% (77/94) in participants who died and 96.7% (26/27) among those who died of CV causes. The incidence of CV death was 14 times higher among those with than those without CAC (9.6% (26/272) vs. 0.7% (1/151); P < 0.01). After adjusting for age, gender, left ventricular hypertrophy, proteinuria, duration of hypertension, and renal function the presence of calcification predicted all cause mortality with a hazard ratio (HR) of 1.8 (95% confidence interval (CI) 1.04-3.07). CONCLUSIONS: CAC is associated with long-term mortality in asymptomatic hypertensive adults.
Authors: Siegfried Adelhoefer; S M Iftekhar Uddin; Albert D Osei; Olufunmilayo H Obisesan; Michael J Blaha; Omar Dzaye Journal: Radiol Cardiothorac Imaging Date: 2020-12-17
Authors: David C Lange; David Glidden; Eric A Secemsky; Karen Ordovas; Steven G Deeks; Jeffrey N Martin; Ann F Bolger; Priscilla Y Hsue Journal: PLoS One Date: 2015-07-01 Impact factor: 3.240
Authors: Valentina Valenti; Bríain Ó Hartaigh; Ran Heo; Joshua Schulman-Marcus; Iksung Cho; Dan K Kalra; Quynh A Truong; Ashley E Giambrone; Heidi Gransar; Tracy Q Callister; Leslee J Shaw; Fay Y Lin; Hyuk-Jae Chang; Sebastiano Sciarretta; James K Min Journal: Int J Cardiol Date: 2015-03-05 Impact factor: 4.164