Literature DB >> 2137203

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus.

X D Fu1, T Maniatis.   

Abstract

A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome assembly. This splicing factor is highly concentrated in discrete regions within the nucleus, in a pattern that is a distinct subset of that seen with anti-snRNP antibodies. These observations are evidence that spliceosome assembly could be compartmentalized within the nucleus.

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Year:  1990        PMID： 2137203     DOI： 10.1038/343437a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  313 in total

Review 1.  Stress and the cell nucleus: dynamics of gene expression and structural reorganization.

Authors:  C Jolly; R I Morimoto
Journal:  Gene Expr       Date:  1999

2.  Assembly of the nuclear transcription and processing machinery: Cajal bodies (coiled bodies) and transcriptosomes.

Authors:  J G Gall; M Bellini; Z Wu; C Murphy
Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138

3.  A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines.

Authors:  T Chen; F M Boisvert; D P Bazett-Jones; S Richard
Journal:  Mol Biol Cell       Date:  1999-09       Impact factor: 4.138

4.  Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides.

Authors:  P Lorenz; T Misteli; B F Baker; C F Bennett; D L Spector
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

5.  Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.

Authors:  D C Barnard; J G Patton
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

6.  Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.

Authors:  I Melcák; S Cermanová; K Jirsová; K Koberna; J Malínský; I Raska
Journal:  Mol Biol Cell       Date:  2000-02       Impact factor: 4.138

7.  Prespliceosomal assembly on microinjected precursor mRNA takes place in nuclear speckles.

Authors:  I Melcák; S Melcáková; V Kopský; J Vecerová; I Raska
Journal:  Mol Biol Cell       Date:  2001-02       Impact factor: 4.138

8.  Initiation of nucleolar assembly is independent of RNA polymerase I transcription.

Authors:  T Dousset; C Wang; C Verheggen; D Chen; D Hernandez-Verdun; S Huang
Journal:  Mol Biol Cell       Date:  2000-08       Impact factor: 4.138

9.  FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles.

Authors:  P Shannon Pendergrast; Chen Wang; Nouria Hernandez; Sui Huang
Journal:  Mol Biol Cell       Date:  2002-03       Impact factor: 4.138

10.  Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA.

Authors:  S Bléoo; X Sun; M J Hendzel; J M Rowe; M Packer; R Godbout
Journal:  Mol Biol Cell       Date:  2001-10       Impact factor: 4.138
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