Literature DB >> 2137201

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist.

S P Eisenberg1, R J Evans, W P Arend, E Verderber, M T Brewer, C H Hannum, R C Thompson.   

Abstract

Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo regulation of IL-1 activity. A complementary DNA for this molecule has been isolated from a human monocyte library. Analysis of monocyte RNA indicates that the gene is transcriptionally regulated. The sequence of the receptor antagonist indicates that it is structurally similar to IL-1 beta. Expression of the cDNA in Escherichia coli yields IL-1 receptor antagonist activity.

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Year:  1990        PMID： 2137201     DOI： 10.1038/343341a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  191 in total

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